ArticleAvicenna journal of phytomedicine
Antidepressant effects of a Persian herbal formula on mice with chronic unpredictable mild stress.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 4 citations in OpenAlex.
- Review
- TM5441, a PAI-1 inhibitor, attenuates chronic stress-induced anxio-depressive-like behaviors by restoring the hippocampal PAI-1/tPA/BDNF axis.Psychopharmacology · 2026Article
- Medicinal Plants for Major Depressive Disorder.Brain sciences · 2026Review
- Effects of Herbal Supplementation on Growth Performance of Kenguri Sheep Exposed to Heat Stress.Animals : an open access journal from MDPI · 2025Article
- Anxiolytic, Antidepressant and Healthy Sleep-Promoting Potential of Rosmarinic Acid: Mechanisms and Molecular Targets.Neuropsychiatric disease and treatment · 2025Review
- Pharmacological Mechanism of Herbal Interventions for Bipolar Disorder.Current pharmaceutical design · 2024Review
- The modulatory role of 6-gingerol-rich portion of ginger on brain oxidative stress, inflammation and neurotransmission in chronic unpredicted mild stress-induced depressed male Wistar rats.Avicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Depression is a serious mental disorder. Despite numerous medications, there are still limitations in depression treatment. So, herbal medicine has been considered an alternative therapy. This survey evaluated the effects of a Persian herbal formula on mice with chronic unpredictable mild stress (CUMS). Materials and Methods: A combination of Results: This formula significantly increased SPT (p<0.001) and decreased immobility time in FST and TST (p<0.01), but it was not effective on EPM vs. CUMS mice. The herbal formula did not change the serum level of creatinine or ALT, but insignificantly reduced cortisol vs. CUMS and vehicle groups. SOD activity increased in the brain vs. vehicle group (p<0.05). There were no changes in histological examination. Conclusion: The herbal formula improved depression-like behaviors which are possibly related to its anti-oxidative effect on the brain. Also, it did not cause any negative changes in the biochemical and histopathological analysis.
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