Evidence map›Paper›PMID 38089014›Full record

ArticleVirus evolution2023

Coevolutionary phage training and Joint application delays the emergence of phage resistance in

Mianzhi Wang, Jingyi Wei, Lei Jiang, Li Jiang, Junxuan Zhang, Xiaolu He, Yiwen Ren, Zixuan Wang, Yongxue Sun, Zhiqiang Wang

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Virus evolution, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 8 citations in OpenAlex.

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  9. Multi-strain phage induced clearance of bacterial infections.bioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 3 countries.

Jingyi WeiJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Daxue Rd 888, Yangzhou, Jiangsu 225009, China.
Lei JiangJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Daxue Rd 888, Yangzhou, Jiangsu 225009, China.
Li JiangJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Daxue Rd 888, Yangzhou, Jiangsu 225009, China.
Junxuan ZhangNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Wushan Rd 483, Guangzhou, Guangdong 510642, China.
Xiaolu HeNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Wushan Rd 483, Guangzhou, Guangdong 510642, China.
Yiwen RenJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Daxue Rd 888, Yangzhou, Jiangsu 225009, China.
Zixuan WangJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Daxue Rd 888, Yangzhou, Jiangsu 225009, China.
Yongxue SunNational Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Wushan Rd 483, Guangzhou, Guangdong 510642, China.
Zhiqiang WangJiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Daxue Rd 888, Yangzhou, Jiangsu 225009, China.
Jiangsu Second Normal University · CNSouth China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotic-resistant bacteria are current threats to available antibiotic therapies, and this has renewed interest in the therapeutic use of phage as an alternative. However, development of phage resistance has led to unsuccessful therapeutic outcomes. In the current study, we applied phage training to minimize bacterial phage resistance and to improve treatment outcome by adapting the phage to their target hosts during co-evolution. We isolated and characterized a novel

Indexed as

antimicrobial-resistant (AMR)coevolutionphage resistancephage therapyphage trainingPseudomonas aeruginosa

Identifiers

PMID38089014
PMCPMC10712906
OpenAlexW4389581555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.