Evidence map›Paper›PMID 38088865›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2024

Sex-specific increases in myostatin and SMAD3 contribute to obesity-related insulin resistance in human skeletal muscle and primary human myotubes.

Gunjan Saxena, Sean Gallagher, Timothy D Law, Dominic Maschari, Erin Walsh, Courtney Dudley, Jeffrey J Brault, Leslie A Consitt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Inflammation-Insulin Resistance Crosstalk and the Central Role of Myokines.International journal of molecular sciences · 2025
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Gunjan SaxenaDepartment of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States.
Sean GallagherHeritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States.
Timothy D LawOhio Musculoskeletal and Neurological Institute, Ohio University, Athens, Ohio, United States.
Dominic MaschariCollege of Health Sciences and Professions, Ohio University, Athens, Ohio, United States.
Erin WalshBiological Sciences Department, Ohio University, Athens, Ohio, United States.
Courtney DudleyBiological Sciences Department, Ohio University, Athens, Ohio, United States.
Jeffrey J BraultDepartment of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, United States.ORCID 0000-0003-3503-0528
Leslie A ConsittDepartment of Biomedical Sciences, Ohio University Heritage College of Osteopathic Medicine, Ohio University, Athens, Ohio, United States.ORCID 0000-0003-2831-9999
Ohio University · USIndiana Hemophilia and Thrombosis Center · US

Funding

CELLULAR ENERGETICS AS A REGULATOR OF MUSCLE MASS AND MITOCHONDRIAL CONTENT DURING MUSCLE ATROPHYR01AR070200 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRAULT, JEFFREY J · 2017 to 2021
$1.6M
Mechanisms of Age-Related Impairments in Human Skeletal Muscle Glucose MetabolismR15AG073922 · NIA · OHIO UNIVERSITY ATHENS · PI CONSITT, LESLIE · 2021 to 2023
$777k
Mechanisms regulating myostatin-induced insulin resistance in skeletal muscleR15DK102115 · NIDDK · OHIO UNIVERSITY ATHENS · PI CONSITT, LESLIE · 2014 to 2014
$371k
NIAMS NIH HHS R01 AR070200NIA NIH HHS R15 AG073922NIDDK NIH HHS R15 DK102115
6 · The paper itself

Abstract

The purpose of the present study was to determine the effects of obesity and biological sex on myostatin expression in humans and to examine the direct effects of myostatin, SMAD2, and SMAD3 on insulin signaling in primary human skeletal muscle cells (HSkMCs). For

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceFemaleHumansInsulinMaleMuscle Fibers, SkeletalMuscle, SkeletalMyostatinObesitySmad3 ProteinInsulinMSTN protein, humanMyostatinSmad3 ProteinSMAD3 protein, humaninsulin sensitivitymyostatinobesityskeletal muscleSMAD3

Identifiers

PMID38088865
PMCPMC11193514
OpenAlexW4389686461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.