Evidence map›Paper›PMID 38088796›Full record

ArticleEmerging microbes & infections2024

Lassa virus in novel hosts: insights into the epidemiology of lassa virus infections in southern Nigeria.

Anise Nkenjop Happi, Olusola Akinola Ogunsanya, Akeemat Opeyemi Ayinla, Ayotunde Elijah Sijuwola, Femi Mudasiru Saibu, Kazeem Akano, Cecilia Nwofoke, Obineche Tobias Elias, Olivia Achonduh-Atijegbe, Richard Olumide Daodu and 27 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. The first imported case of Lassa fever in China: a case description.Quantitative imaging in medicine and surgery · 2025
    Article
  10. Article
  11. Lassa Fever: Critical Review and Prospects for Control.Tropical medicine and infectious disease · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors at 8 institutions in 2 countries.

Anise Nkenjop HappiAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Olusola Akinola OgunsanyaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Akeemat Opeyemi AyinlaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Ayotunde Elijah SijuwolaAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Femi Mudasiru SaibuAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Kazeem AkanoAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Cecilia NwofokeAlex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria.
Obineche Tobias EliasUniversity of Nigeria, Nsukka, Nigeria.
Olivia Achonduh-AtijegbeAlex Ekwueme Federal University Teaching Hospital, Abakaliki, Ebonyi State, Nigeria.
Richard Olumide DaoduAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Oluwatobi Abel AdedokunAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Abraham AdeyemoAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Kehinde Ebenezer OgundanaRedeemer's University, Ede, Osun, Nigeria.
Omolola Zaheedat LawalRedeemer's University, Ede, Osun, Nigeria.
Edyth ParkerScripps Translational Science Institute, La Jolla, CA, USA.
Iguosadolo NosamiefanAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Johnson OkolieAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Zahra F ParkerHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Melanie D McCauleyHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Leigh Anne EllerHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Kara LombardiHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Abdulwasiu Bolaji TiamiyuHenry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, Nigeria.
Michael IroezinduHenry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, Nigeria.
Edward AkinwaleHenry M. Jackson Foundation Medical Research International Ltd/Gte, Abuja, Nigeria.
Thierry Lamare Fouapon Assedi NjatouOne Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Tsedal MebrahtuHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Erica BroachHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Anastasia ZuppeHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Petra PrinsHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Jenny LayHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Mihret AmareHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Kayvon ModjarradEmerging Infectious Diseases Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Natalie D CollinsViral Diseases Program, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Sandhya VasanHenry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
Cynthia TuckerOne Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Sharon DayeOne Health Branch, Center for Infectious Diseases Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Christian Tientcha HappiAfrican Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Osun State, Nigeria.
Henry M. Jackson Foundation · USRedeemer's University · NGWalter Reed Army Institute of Research · USFederal Teaching Hospital Abakaliki · NGHarvard University · USJackson Foundation · USScripps Research Institute · USUniversity of Nigeria · NG

Funding

Utilize Microbial Metagenomics for Viral Pathogen CharacterizationU54HG007480 · NHGRI · REDEEMER'S UNIVERSITY · PI HAPPI, CHRISTIAN T. · 2017 to 2022
$5.5M
Host and Microbial Genetic Determinants of Febrile Illness in West AfricaU01HG007480 · NHGRI · REDEEMER'S UNIVERSITY · PI HAPPI, CHRISTIAN T. · 2013 to 2016
$1.6M
NHGRI NIH HHS U01 HG007480NHGRI NIH HHS U54 HG007480
6 · The paper itself

Abstract

Identification of the diverse animal hosts responsible for spill-over events from animals to humans is crucial for comprehending the transmission patterns of emerging infectious diseases, which pose significant public health risks. To better characterize potential animal hosts of Lassa virus (LASV), we assessed domestic and non-domestic animals from 2021-2022 in four locations in southern Nigeria with reported cases of Lassa fever (LF). Birds, lizards, and domestic mammals (dogs, pigs, cattle and goats) were screened using RT-qPCR, and whole genome sequencing was performed for lineage identification on selected LASV positive samples. Animals were also screened for exposure to LASV by enzyme-linked immunosorbent assay (ELISA). Among these animals, lizards had the highest positivity rate by PCR. Genomic sequencing of samples in most infected animals showed sub-lineage 2 g of LASV. Seropositivity was highest among cattle and lowest in pigs. Though the specific impact these additional hosts may have in the broader virus-host context are still unknown - specifically relating to pathogen diversity, evolution, and transmission - the detection of LASV in non-rodent hosts living in proximity to confirmed human LF cases suggests their involvement during transmission as potential reservoirs. Additional epidemiological data comparing viral genomes from humans and animals, as well as those circulating within the environment will be critical in understanding LASV transmission dynamics and will ultimately guide the development of countermeasures for this zoonotic health threat.

Indexed as

Lassa FeverLassa virusAnimalsCattleDogsGenome, ViralHumansMammalsNigeriaPublic HealthSwineanimalsLassa virusLASV genomesLASV lineages 2 gNigerianon-rodents

Identifiers

PMID38088796
PMCPMC10810657
OpenAlexW4389673334

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.