ArticleJournal of the American Heart Association2023
Trends in Infective Endocarditis Mortality in the United States: 1999 to 2020: A Cause for Alarm.
Article in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Optimizing Treatment of Infective Endocarditis in Patients Who Inject Drugs.Antibiotics (Basel, Switzerland) · 2026Review
- Substance Use-Associated Infective Endocarditis Mortality in Young U.S. Adults, 2018 to 2024.JACC. Advances · 2026Article
- Article
- A Peer-Led, Narrative-Based, and Mobile-Supported Intervention in Opioid Use Disorder: Multiphase Qualitative and Longitudinal Observational Study.JMIR formative research · 2026Observational
- Trends and disparities in mortality from infective endocarditis in the United States, 1999-2023: a nationwide analysis.Frontiers in cardiovascular medicine · 2026Article
- From decline to rebound: a 25-year Joinpoint analysis of tuberculosis mortality in the United States, 1999-2023.BMC infectious diseases · 2025Article
- Mitral Valve Repair for the Treatment of Acute Bacterial Endocarditis: Analysis of a 10-Year Single-Center Experience.Journal of clinical medicine · 2025Article
- Clinical features and outcomes of infective endocarditis in persons experiencing homelessness.Infectious diseases of poverty · 2025Article
- Trends of infective endocarditis mortality in young adult population of US: A concerning rise and its association with substance abuse.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Epidemiology of Valvular Heart Disease in Asia Pacific Region.JACC. Asia · 2025Review
- Trends in the Management of Infective Endocarditis for Patients Who Inject Drugs: A Survey of Healthcare Facilities in Tennessee.Open forum infectious diseases · 2025Article
- Association Between Inpatient Medication Treatment for Opioid Use Disorder and Reduced One-Year All-Cause Mortality in Patients With Invasive Bacterial Infections.Open forum infectious diseases · 2025Article
- Article
- Acute drug-use-related native tricuspid valve infective endocarditis: a non-surgical disease.Therapeutic advances in infectious diseaseReview
- Relevance of cardiac imaging in the evolving landscape of infective endocarditis management.Therapeutic advances in cardiovascular diseaseReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on national trends in mortality due to infective endocarditis (IE) in the United States are limited. METHODS AND
resultsUtilizing the multiple causes of death data from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research database from 1999 to 2020, IE and substance use were identified using
conclusionsAge-adjusted mortality rates due to IE in the overall population have declined. The marked acceleration in mortality in the 25- to 44-year age group is a cause for alarm. Regional differences with acceleration in IE mortality rates were noted in Kentucky, Tennessee, and West Virginia. We speculate that this acceleration was likely due mainly to the opioid crisis that has engulfed several states and involved principally younger adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.