Evidence map›Paper›PMID 38087458›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2024

Age-associated Senescent - T Cell Signaling Promotes Type 3 Immunity that Inhibits the Biomaterial Regenerative Response.

Jin Han, Christopher Cherry, Joscelyn C Mejías, Kavita Krishnan, Anna Ruta, David R Maestas, Alexis N Peña, Helen Hieu Nguyen, Sushma Nagaraj, Brenda Yang and 10 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Antibiotic-induced microbiota depletion impairs the proregenerative response to a biological scaffold.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Murine gut microbiota dysbiosis via enteric infection modulates the foreign body response to a distal biomaterial implant.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. General and individualized changes in T cell immunity during aging.Journal of immunology (Baltimore, Md. : 1950) · 2025
    Review
  9. Article
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Jin HanTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.ORCID 0000-0001-8799-5140
Christopher CherryTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Joscelyn C MejíasTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Kavita KrishnanTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Anna RutaTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
David R MaestasTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Alexis N PeñaTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Helen Hieu NguyenTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Sushma NagarajDepartment of Neurology, Brain Science Institute, Johns Hopkins University, Baltimore, MD, 21231, USA.
Brenda YangTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Elise F Gray-GaillardTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Natalie RutkowskiTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Maria BrowneTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.
Ada J TamBloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Elana J FertigDepartment of Biomedical Engineering and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21218, USA.
Franck HousseauBloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Sudipto GangulyBloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Erika M MooreFischell Department of Bioengineering, University of Maryland, College Park, MD, 20742, USA.
Drew M PardollBloomberg∼Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Jennifer H ElisseeffTranslational Tissue Engineering Center, Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, 21231, USA.ORCID 0000-0002-5066-1996
Johns Hopkins University · USBloomberg (United States) · USUniversity of Florida · US

Funding

Biomaterials-directed regenerative immunotherapiesDP1AR076959 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2019 to 2023
$5.7M
Develop BCL-xL proteolysis targeting chimeras as safer and better senolyticsR01AG063801 · NIA · UNIVERSITY OF FLORIDA · PI ELISSEEFF, JENNIFER H, ZHENG, GUANGRONG · 2019 to 2023
$2.6M
Single cell characterization of the biomaterial immune and stromal responseR01EB028796 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI ELISSEEFF, JENNIFER H · 2020 to 2023
$2.5M
Age and sex differences in the immune response to synthetic materialsR00AG081564 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI Joscelyn Claraluz Mejias · 2025 to 2026
$488k
Age and sex differences in the immune response to synthetic materialsK99AG081564 · NIA · JOHNS HOPKINS UNIVERSITY · PI MEJIAS, JOSCELYN CLARALUZ · 2023 to 2024
$202k
NIAMS NIH HHS DP1 AR076959NIA NIH HHS K99 AG081564NIA NIH HHS R00 AG081564NIA NIH HHS R01 AG063801NIBIB NIH HHS R01 EB028796NIH HHS DP1AR076959NIH HHS R01AG063801
6 · The paper itself

Abstract

Aging is associated with immunological changes that compromise response to infections and vaccines, exacerbate inflammatory diseases and can potentially mitigate tissue repair. Even so, age-related changes to the immune response to tissue damage and regenerative medicine therapies remain unknown. Here, it is characterized how aging induces changes in immunological signatures that inhibit tissue repair and therapeutic response to a clinical regenerative biological scaffold derived from extracellular matrix. Signatures of inflammation and interleukin (IL)-17 signaling increased with injury and treatment both locally and regionally in aged animals, and computational analysis uncovered age-associated senescent-T cell communication that promotes type 3 immunity in T cells. Local inhibition of type 3 immune activation using IL17-neutralizing antibodies improves healing and restores therapeutic response to the regenerative biomaterial, promoting muscle repair in older animals. These results provide insights into tissue immune dysregulation that occurs with aging that can be targeted to rejuvenate repair.

Indexed as

AgingBiocompatible MaterialsSignal TransductionT-LymphocytesAnimalsCellular SenescenceExtracellular MatrixInterleukin-17MiceMice, Inbred C57BLRegenerationRegenerative MedicineTissue ScaffoldsWound HealingBiocompatible MaterialsInterleukin-17agingbiomaterialssenescencetissue engineering

Identifiers

PMID38087458
PMCPMC12522171
OpenAlexW4389683686

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.