Evidence map›Paper›PMID 38087382›Full record

ArticleStem cell research & therapy2023

Umbilical cord mesenchymal stromal cells in serum-free defined medium display an improved safety profile.

Xiaoyun Wu, Zhijie Ma, Yuxiao Yang, Yongxu Mu, Daocheng Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Xiaoyun WuKey Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.
Zhijie MaDepartment of Pharmacy, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.
Yuxiao YangDepartment of Technology, Beijing Stem Cell (ProterCell) Biotechnology Co., Ltd., Beijing, People's Republic of China.
Yongxu MuInterventional Department, The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, People's Republic of China.
Daocheng WuKey Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China. wudaocheng@mail.xjtu.edu.cn.ORCID 0000-0002-6183-539X
Inner Mongolia University of Science and Technology · CNCapital Medical University · CNInner Mongolia People's Hospital · CNXi'an Jiaotong University · CN

Funding

National Natural Science Foundation of China 81960252Natural Science Foundation of Beijing 7222267Natural Science Foundation of Inner Mongolia 2021LHMS08019Natural Science Foundation of Inner Mongolia 2021LHMS08023
6 · The paper itself

Abstract

backgroundSafety evaluations in preclinical studies are needed to confirm before translating a cell-based product into clinical application. We previously developed a serum-free, xeno-free, and chemically defined media (S&XFM-CD) for the derivation of clinical-grade umbilical cord-derived MSCs (UCMSCs), and demonstrated that intraperitoneal administration of UCMSCs in S&XFM-CD (UCMSC

methodsIn this study, the toxicity, immunogenicity and biodistribution of intraperitoneally transplanted UCMSC

resultsWe confirmed that intraperitoneally transplanted UCMSC

conclusionsTaken together, our data indicate that UCMSC

Indexed as

Mesenchymal Stem CellsNeoplasmsAnimalsCytokinesHumansMiceMice, NudeRatsTissue DistributionUmbilical CordCytokinesImmunogenicityMesenchymal stromal cellsSafetySerum freeTumorigenicityUmbilical cord

Identifiers

PMID38087382
PMCPMC10717764
OpenAlexW4389612632

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.