Evidence map›Paper›PMID 38087216›Full record

SynthesisBMC surgery2023

Effectiveness and safety analysis of titanium mesh grafting versus bone grafting in the treatment of spinal Tuberculosis: a systematic review and meta-analysis.

Fangfang Deng, Bo Chen, Huali Guo, Qingqing Chen, Feifan Wang

Open access · goldAbstract readComparative StudyMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Fangfang DengThe First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang Hubei, 443000, China.
Bo ChenThe First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang Hubei, 443000, China.
Huali GuoThe First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang Hubei, 443000, China.
Qingqing ChenThe First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang Hubei, 443000, China.
Feifan WangThe First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang Hubei, 443000, China. 66081092@qq.com.
Yichang Central People's Hospital · CNChina Three Gorges University · CN

Funding

Construction and Clinical practice of standardized nursing plan for spinal tuberculosis during perioperative period, Yichang Medical and Health Science and Technology Project Project A21-2-023
6 · The paper itself

Abstract

backgroundTo systematically assess the safety and effectiveness of titanium mesh grafting compared with bone grafting in the treatment of spinal tuberculosis.

methodsElectronic databases, including PubMed, Embase, Web of Science, and Cochrane Library, were searched from their inception until April 2023. The outcome indicators for patients treated with titanium mesh grafting or bone grafting for spinal tuberculosis include surgical duration, intraoperative blood loss, graft fusion time, American Spinal Injury Association (ASIA) Spinal Cord Injury Grade E assessment, VAS score, lumbar pain score, post-graft kyphotic angle, and postoperative complications. The Newcastle-Ottawa Scale (NOS) and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach were used for quality assessment and evidence grading of clinical studies. Funnel plots and Begg's test were employed for bias assessment.

resultsA total of 8 studies were finally included, comprising 523 patients, with 267 cases of titanium mesh fixation and 256 cases of bone grafting. The meta-analysis showed no significant statistical differences in surgical duration (Weighted Mean Difference (WMD) = -7.20, 95% Confidence Interval (CI): -28.06 to 13.67, P = 0.499), intraoperative blood loss (WMD = 16.22, 95% CI: -40.62 to 73.06, P = 0.576), graft fusion time (WMD = 0.97, 95% CI: -0.88 to 2.81, P = 0.304), ASIA Spinal Cord Injury Grade E assessment (Relative Risk (RR) = 1.03, 95% CI: 0.97 to 1.09, P = 0.346), and overall complications (RR = 0.87, 95% CI: 0.49 to 1.55, P = 0.643). Differences in VAS score, ODI lumbar pain score, and post-graft kyphotic angle between the titanium mesh grafting group and the bone grafting group were not significant within the 95% CI range. The rate of postoperative implant subsidence was slightly lower in bone grafting than in titanium mesh grafting (RR = 9.30, 95% CI: 1.05 to 82.22, P = 0.045).

conclusionsBoth bone grafting and titanium mesh grafting are effective and safe for the surgery, with no significant statistical differences in the results. Considering the limitations of the present study, large-scale randomized controlled trials are warranted to further verify the reliability of this finding.

Indexed as

KyphosisLow Back PainSpinal Cord InjuriesSpinal FusionTuberculosis, SpinalBlood Loss, SurgicalBone TransplantationHumansLumbar VertebraeReproducibility of ResultsRetrospective StudiesSurgical MeshThoracic VertebraeTitaniumTreatment OutcomeTitaniumBone graftingMeta-analysisSpinal TuberculosisSurgical TreatmentTitanium Mesh Grafting

Identifiers

PMID38087216
PMCPMC10717474
OpenAlexW4389612416

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.