Evidence map›Paper›PMID 38087161›Full record

Observational studyJournal of assisted reproduction and genetics2024

Bacterial vaginosis in a subfertile population undergoing fertility treatments: a prospective cohort study.

Marjolein M van den Tweel, Ellen H A van den Munckhof, Moniek van der Zanden, Anco C Molijn, Jan M M van Lith, Saskia Le Cessie, Kim E Boers

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of assisted reproduction and genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. The Vaginal Microbiome Changes During Various Fertility Treatments.Reproductive sciences (Thousand Oaks, Calif.) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Marjolein M van den TweelDepartment of Obstetrics and Gynecology, Leiden University Medical Center, 2300RC, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-6443-2097
Ellen H A van den MunckhofDDL Diagnostic Laboratory, 2288ER, Rijswijk, The Netherlands.
Moniek van der ZandenDepartment of Obstetrics and Gynecology, Haaglanden Medical Center, Bronovolaan 5, 2597AX, The Hague, The Netherlands.
Anco C MolijnEurofins NMDL-LCPL, 2288ER, Rijswijk, The Netherlands.
Jan M M van LithDepartment of Obstetrics and Gynecology, Leiden University Medical Center, 2300RC, Leiden, The Netherlands.
Saskia Le CessieDepartment of Biomedical Data Sciences, Leiden University Medical Center, 2300RC, Leiden, The Netherlands.
Kim E BoersDepartment of Obstetrics and Gynecology, Haaglanden Medical Center, Bronovolaan 5, 2597AX, The Hague, The Netherlands. kim.boers@haaglandenmc.nl.
Leiden University Medical Center · NLMedisch Centrum Haaglanden · NLDDL Diagnostic Laboratory · NLEurofins (Netherlands) · NL

Funding

Haaglanden Medisch Centrum 2021
6 · The paper itself

Abstract

purposeThis study investigates the role of bacterial vaginosis (BV) on pregnancy rates during various fertility treatments. BV is known to influence several obstetric outcomes, such as preterm delivery and endometritis. Only few studies investigated the effect of BV in subfertile women, and studies found a negative effect on fecundity especially in the in vitro fertilisation population.

methodsObservational prospective study, 76 couples attending a fertility clinic in the Netherlands between July 2019 and June 2022, undergoing a total of 133 attempts of intra uterine insemination, in vitro fertilization or intra cytoplasmatic sperm injection. Vaginal samples taken at oocyte retrieval or insemination were analysed on qPCR BV and 16S rRNA gene microbiota analysis of V1-V2 region. Logistic regression with a Generalized Estimated Equations analysis was used to account for multiple observations per couples.

resultsA total of 26% of the 133 samples tested positive for BV. No significant differences were observed in ongoing pregnancy or live birth rates based on BV status (OR 0.50 (0.16-1.59), aOR 0.32 (0.09-1.23)) or microbiome community state type. There was a tendency of more miscarriages based on positive BV status (OR 4.22 (1.10-16.21), aOR 4.28 (0.65-28.11)) or community state type group III and IV. On baseline qPCR positive participants had significantly higher body mass index and smoked more often. Odds ratios were adjusted for smoking status, body mass index, and socioeconomic status.

conclusionBacterial vaginosis does not significantly impact ongoing pregnancy rates but could affect miscarriage rates.

Indexed as

Abortion, SpontaneousInfertilityVaginosis, BacterialFemaleFertilityFertilization in VitroHumansInfant, NewbornMalePregnancyPregnancy RateProspective StudiesRNA, Ribosomal, 16SSemenRNA, Ribosomal, 16SBacterial vaginosisIUIIVFMicrobiomeSubfertility

Identifiers

PMID38087161
PMCPMC10894785
OpenAlexW4389683963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.