Evidence map›Paper›PMID 38087072›Full record

ArticleCell and tissue research2024

Cellular heterogeneity in red and melanized focal muscle changes in farmed Atlantic salmon (Salmo salar) visualized by spatial transcriptomics.

H Bjørgen, S Malik, E Rimstad, M Vaadal, I B Nyman, E O Koppang, T Tengs

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell and tissue research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

H BjørgenUnit of Anatomy, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, 1433, Ås, Norway.
S MalikDepartment of Breeding and Genetics, Nofima, 1433, Ås, Norway.
E RimstadUnit of Virology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, 1433, Ås, Norway.
M VaadalDepartment of Breeding and Genetics, Nofima, 1433, Ås, Norway.
I B NymanUnit of Virology, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, 1433, Ås, Norway.
E O KoppangUnit of Anatomy, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, 1433, Ås, Norway.
T TengsDepartment of Breeding and Genetics, Nofima, 1433, Ås, Norway. torstein.tengs@nofima.no.ORCID http://orcid.org/0000-0001-9695-6063
Norwegian University of Life Sciences · NONofima · NO

Funding

Fiskeri - og havbruksnæringens forskningsfond 901501Horizon 2020 Framework Programme 818367
6 · The paper itself

Abstract

Spatial transcriptomics is a technique that provides insight into gene expression profiles in tissue sections while retaining structural information. We have employed this method to study the pathological conditions related to red and melanized focal changes in farmed Atlantic salmon (Salmo salar). Our findings support a model where similar molecular mechanisms are involved in both red and melanized filet discolorations and genes associated with several relevant pathways show distinct expression patterns in both sample types. Interestingly, there appears to be significant cellular heterogeneity in the foci investigated when looking at gene expression patterns. Some of the genes that show differential spatial expression are involved in cellular processes such as hypoxia and immune responses, providing new insight into the nature of muscle melanization in Atlantic salmon.

Indexed as

Fish DiseasesReoviridae InfectionsSalmo salarAnimalsGene Expression ProfilingMuscle, SkeletalTranscriptomeAtlantic salmonHypoxiaMelanizationPRV-1Spatial transcriptomics

Identifiers

PMID38087072
PMCPMC10837230
OpenAlexW4389683718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.