ArticleCommunications biology2023
Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Demographics change the relationships between socioeconomic status, white matter network organization, and cognition in children.Developmental cognitive neuroscience · 2026Article
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Atypical development of white matter structural networks in children and adolescents with autism spectrum disorder: a graph theory study.Frontiers in neuroscience · 2026Article
- Social exclusion in educational settings and the risk of alienation in adolescent development: a narrative review from a mind-body interaction perspective.Frontiers in psychology · 2026Review
- Multimodal brain network disruption and structural-functional decoupling in overt hypothyroidism.Frontiers in endocrinology · 2026Article
- Cellular and molecular associations with intrinsic brain organization.Nature communications · 2025Article
- Cellular and molecular associations with intrinsic brain organization.bioRxiv : the preprint server for biology · 2025Article
- Mapping striatal functional gradients and associated gene expression in Parkinson's disease with continuous cognitive impairment.NPJ Parkinson's disease · 2025Article
- The importance of sleep for the developing brain.Current sleep medicine reports · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors.
Funding
Abstract
From childhood to adolescence, the spatiotemporal development pattern of the human brain white matter connectome and its underlying transcriptomic and cellular mechanisms remain largely unknown. With a longitudinal diffusion MRI cohort of 604 participants, we map the developmental trajectory of the white matter connectome from global to regional levels and identify that most brain network properties followed a linear developmental trajectory. Importantly, connectome-transcriptomic analysis reveals that the spatial development pattern of white matter connectome is potentially regulated by the transcriptomic architecture, with positively correlated genes involve in ion transport- and development-related pathways expressed in excitatory and inhibitory neurons, and negatively correlated genes enriches in synapse- and development-related pathways expressed in astrocytes, inhibitory neurons and microglia. Additionally, the macroscale developmental pattern is also associated with myelin content and thicknesses of specific laminas. These findings offer insights into the underlying genetics and neural mechanisms of macroscale white matter connectome development from childhood to adolescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.