Evidence map›Paper›PMID 38087028›Full record

ArticleNPJ digital medicine2023

Prediction of atrial fibrillation from at-home single-lead ECG signals without arrhythmias.

Matteo Gadaleta, Patrick Harrington, Eric Barnhill, Evangelos Hytopoulos, Mintu P Turakhia, Steven R Steinhubl, Giorgio Quer

Open access · goldAbstract read
In one paragraph

Article in NPJ digital medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.

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  6. Wearable Flexible Sensors for Cardiovascular Disease Monitoring.Advanced materials (Deerfield Beach, Fla.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matteo GadaletaScripps Research Translational Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-6470-6537
Patrick HarringtoniRhythm Technologies, San Francisco, CA, USA.
Eric BarnhilliRhythm Technologies, San Francisco, CA, USA.
Evangelos HytopoulosiRhythm Technologies, San Francisco, CA, USA.
Mintu P TurakhiaiRhythm Technologies, San Francisco, CA, USA.
Steven R SteinhublScripps Research Translational Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-9256-7914
Giorgio QuerScripps Research Translational Institute, La Jolla, CA, USA. gquer@scripps.edu.ORCID http://orcid.org/0000-0003-2208-7912
iRhythm (United States) · USScripps Research Institute · US

Funding

Scripps Translational Science InstituteUL1TR002550 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2018 to 2022
$28.9M
Scripps Clinical and Translational Science HubUM1TR004407 · NCATS · SCRIPPS RESEARCH INSTITUTE, THE · PI Eric Jeffrey Topol · 2023 to 2026
$24.2M
Predicting Short- and Long-term Future Occurrence of Atrial Fibrillation from Single-Lead ECG in Normal Sinus Rhythm with an Explainable Deep Learning Model.R21AG072349 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI QUER, GIORGIO · 2021 to 2022
$488k
NCATS NIH HHS UL1 TR002550NCATS NIH HHS UM1 TR004407NIA NIH HHS R21 AG072349
6 · The paper itself

Abstract

Early identification of atrial fibrillation (AF) can reduce the risk of stroke, heart failure, and other serious cardiovascular outcomes. However, paroxysmal AF may not be detected even after a two-week continuous monitoring period. We developed a model to quantify the risk of near-term AF in a two-week period, based on AF-free ECG intervals of up to 24 h from 459,889 patch-based ambulatory single-lead ECG (modified lead II) recordings of up to 14 days. A deep learning model was used to integrate ECG morphology data with demographic and heart rhythm features toward AF prediction. Observing a 1-day AF-free ECG recording, the model with deep learning features produced the most accurate prediction of near-term AF with an area under the curve AUC = 0.80 (95% confidence interval, CI = 0.79-0.81), significantly improving discrimination compared to demographic metrics alone (AUC 0.67; CI = 0.66-0.68). Our model was able to predict incident AF over a two-week time frame with high discrimination, based on AF-free single-lead ECG recordings of various lengths. Application of the model may enable a digital strategy for improving diagnostic capture of AF by risk stratifying individuals with AF-negative ambulatory monitoring for prolonged or recurrent monitoring, potentially leading to more rapid initiation of treatment.

Identifiers

PMID38087028
PMCPMC10716265
OpenAlexW4389617987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.