ArticleCommunications biology2023
Hypothalamic supramammillary neurons that project to the medial septum modulate wakefulness in mice.
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Hippocampal long-range GABAergic neurons target hippocampal-projecting cells of the supramammillary area.The Journal of physiology · 2026Article
- Article
- Role of Preoptic Area γ-Aminobutyric Acid-mediated Neurons in Distinctly Regulating Sleep and Rousability during Dexmedetomidine Sedation in Mice.Anesthesiology · 2026Article
- Anesthetic State-Dependent Bidirectional Control of States of Consciousness via Heterogeneous Medial Septum to Ventral Tegmental Area Circuits under Sevoflurane in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Article
- Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain.Frontiers in neuroanatomy · 2026Article
- Activation of Glutamatergic Neurons in the Supramammillary Nucleus Promotes the Recovery of Consciousness under Sevoflurane Anesthesia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Electrophysiological activity pattern of mouse hippocampal CA1 and dentate gyrus under isoflurane anesthesia.Frontiers in cellular neuroscience · 2024Article
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
Abstract
The hypothalamic supramammillary nucleus (SuM) plays a crucial role in controlling wakefulness, but the downstream target regions participating in this control process remain unknown. Here, using circuit-specific fiber photometry and single-neuron electrophysiology together with electroencephalogram, electromyogram and behavioral recordings, we find that approximately half of SuM neurons that project to the medial septum (MS) are wake-active. Optogenetic stimulation of axonal terminals of SuM-MS projection induces a rapid and reliable transition to wakefulness from non-rapid-eye movement or rapid-eye movement sleep, and chemogenetic activation of SuM
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.