Evidence map›Paper›PMID 38086958›Full record

ArticleScientific reports2023

Heavy-chain antibody targeting of CD38 NAD

Bo Shi, Asif Amin, Pranjali Dalvi, Wenxia Wang, Nicholas Lukacs, Li Kai, Paul Cheresh, Thais R Peclat, Claudia C Chini, Eduardo N Chini and 2 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Bo ShiNorthwestern Scleroderma Program, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Asif AminDepartment of Internal Medicine, The University of Michigan, Ann Arbor, MI, 48109, USA.
Pranjali DalviTeneobio Inc., Menlo Park, CA, 94025, USA.
Wenxia WangNorthwestern Scleroderma Program, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Nicholas LukacsDepartment of Pathology, The University of Michigan, Ann Arbor, MI, 48109, USA.
Li KaiNorthwestern Scleroderma Program, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Paul ChereshDivision of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.
Thais R PeclatDepartment of Anesthesiology and Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.
Claudia C ChiniDepartment of Anesthesiology and Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.
Eduardo N ChiniDepartment of Anesthesiology and Kogod Center on Aging, Mayo Clinic, Jacksonville, FL, USA.
Wim van SchootenTeneobio Inc., Menlo Park, CA, 94025, USA.
John VargaDepartment of Internal Medicine, The University of Michigan, Ann Arbor, MI, 48109, USA. vargaj@med.umich.edu.
Northwestern University · USATUM (United States) · USJacksonville College · USUniversity of Michigan · USMayo Clinic in Florida · USScleroderma Foundation · US

Funding

Therapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0M
CD38 modulation of NAD metabolism driving scleroderma pathogenesisR01AR081788 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eduardo N Chini, John Varga · 2023 to 2026
$2.6M
Role of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0M
Targeting NAD metabolism to treat systemic sclerosisR21AR074523 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHINI, EDUARDO N, VARGA, JOHN · 2018 to 2019
$396k
NCI NIH HHS R01 CA233790NIAMS NIH HHS R01 AR081788NIAMS NIH HHS R21 AR074523NIA NIH HHS R01 AG058812
6 · The paper itself

Abstract

The functionally pleiotropic ectoenzyme CD38 is a glycohydrolase widely expressed on immune and non-hematopoietic cells. By converting NAD

Indexed as

Antigens, CDAntigens, DifferentiationADP-ribosyl CyclaseADP-ribosyl Cyclase 1AnimalsFibrosisGlycoside HydrolasesMembrane GlycoproteinsMiceNADNAD+ NucleosidaseADP-ribosyl CyclaseADP-ribosyl Cyclase 1Antigens, CDAntigens, DifferentiationGlycoside HydrolasesMembrane GlycoproteinsNADNAD+ Nucleosidase

Identifiers

PMID38086958
PMCPMC10716202
OpenAlexW4389609399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.