Evidence map›Paper›PMID 38086901›Full record

SynthesisNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024

A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.

Dhvani D Mehta, Angela Praecht, Heather B Ward, Marcos Sanches, Maryam Sorkhou, Victor M Tang, Vaughn R Steele, Colleen A Hanlon, Tony P George

Registry-linked trialOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06830980 (TMS), which is not on this map. Cited by 78 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 7 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06830980 nacompletednot on this mapstarted 2025, after this paper: background citation

TMS (Transcranial Magnetic Stimulation) for Methamphetamine Use Disorder in People Living With HIV

TypeinterventionalSponsorGopalkumar RakeshRan2025 to 2026Enrolled12ConditionsMethamphetamine Use Disorders, HIVArmsintermittent theta burst stimulation (iTBS), continuous theta burst stimulation (cTBS), Sham TMS
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 7 syntheses or guidelines pooled it, 109 citations in OpenAlex.

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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Dhvani D MehtaAddictions Division, CAMH, Toronto, ON, Canada. dhvani.mehta@mail.utoronto.ca.
Angela PraechtAddictions Division, CAMH, Toronto, ON, Canada.
Heather B WardDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-2901-8004
Marcos SanchesAddictions Division, CAMH, Toronto, ON, Canada.
Maryam SorkhouAddictions Division, CAMH, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-4695-9586
Victor M TangAddictions Division, CAMH, Toronto, ON, Canada.ORCID http://orcid.org/0000-0001-5365-9683
Vaughn R SteeleDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-7903-2114
Colleen A HanlonBrainsway, Inc., Winston-Salem, NC, USA.ORCID http://orcid.org/0000-0002-3151-0279
Tony P GeorgeAddictions Division, CAMH, Toronto, ON, Canada. tony.george@camh.ca.ORCID http://orcid.org/0000-0003-1645-9767
Centre for Addiction and Mental Health · CAVanderbilt University Medical Center · USYale University · US

Funding

Effects of rTMS on Cannabis Use and Cognitive Outcomes in SchizophreniaR21DA043949 · NIDA · CENTRE FOR ADDICTION AND MENTAL HEALTH · PI GEORGE, TONY P · 2017 to 2018
$286k
NIDA NIH HHS R21 DA043949
6 · The paper itself

Abstract

While pharmacological, behavioral and psychosocial treatments are available for substance use disorders (SUDs), they are not always effective or well-tolerated. Neuromodulation (NM) methods, including repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS) and deep brain stimulation (DBS) may address SUDs by targeting addiction neurocircuitry. We evaluated the efficacy of NM to improve behavioral outcomes in SUDs. A systematic literature search was performed on MEDLINE, PsychINFO, and PubMed databases and a list of search terms for four key concepts (SUD, rTMS, tDCS, DBS) was applied. Ninety-four studies were identified that examined the effects of rTMS, tDCS, and DBS on substance use outcomes (e.g., craving, consumption, and relapse) amongst individuals with SUDs including alcohol, tobacco, cannabis, stimulants, and opioids. Meta-analyses were performed for alcohol and tobacco studies using rTMS and tDCS. We found that rTMS reduced substance use and craving, as indicated by medium to large effect sizes (Hedge's g > 0.5). Results were most encouraging when multiple stimulation sessions were applied, and the left dorsolateral prefrontal cortex (DLPFC) was targeted. tDCS also produced medium effect sizes for drug use and craving, though they were highly variable and less robust than rTMS; right anodal DLPFC stimulation appeared to be most efficacious. DBS studies were typically small, uncontrolled studies, but showed promise in reducing misuse of multiple substances. NM may be promising for the treatment of SUDs. Future studies should determine underlying neural mechanisms of NM, and further evaluate extended treatment durations, accelerated administration protocols and long-term outcomes with biochemical verification of substance use.

Indexed as

Deep Brain StimulationSubstance-Related DisordersTranscranial Direct Current StimulationTranscranial Magnetic StimulationHumans

Identifiers

PMID38086901
PMCPMC10876556
OpenAlexW4389614685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.