Evidence map›Paper›PMID 38086873›Full record

ArticleScientific reports2023

Bundling of collagen fibrils influences osteocyte network formation during bone modeling.

Mana Hashimoto, Haruka Takahashi, Kaori Tabata-Okubo, Noriyuki Nagaoka, Kazuaki Tokunaga, Haruka Matsumori, Yoshihito Ishihara, Masaru Kaku, Tadahiro Iimura, Toru Hara and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Mana HashimotoDepartment of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-Ku, Okayama, Okayama, 700-8525, Japan.
Haruka TakahashiDepartment of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-Ku, Okayama, Okayama, 700-8525, Japan.
Kaori Tabata-OkuboDepartment of Orthodontics, Okayama University Hospital, 2-5-1, Shikata-cho, Kita-Ku, Okayama, Okayama, 700-8525, Japan.
Noriyuki NagaokaAdvanced Research Center for Oral and Craniofacial Sciences, Okayama University Dental School, 2-5-1, Shikata-cho, Kita-Ku, Okayama, Okayama, 700-8525, Japan.
Kazuaki TokunagaNikon Corporation, 2-15-3 Konan, Minato-Ku, Tokyo, 108-6290, Japan.
Haruka MatsumoriNikon Corporation, 2-15-3 Konan, Minato-Ku, Tokyo, 108-6290, Japan.
Yoshihito IshiharaDepartment of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-Ku, Okayama, Okayama, 700-8525, Japan.
Masaru KakuDivision of Bio-prosthodontics, Faculty of Dentistry and Graduate School of Medical and Dental Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo-Ku, Niigata, Niigata, 951-8514, Japan.
Tadahiro IimuraDepartment of Pharmacology, Faculty and Graduate School of Dental Medicine, Hokkaido University, N13 W7, Kita-Ku, Sapporo, Hokkaido, 060-8586, Japan.
Toru HaraResearch Center for Structural Materials, National Institute for Materials Science, 1-2-1, Sengen, Tsukuba, Ibaraki, 305-0047, Japan.
Hiroshi KamiokaDepartment of Orthodontics, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-Ku, Okayama, Okayama, 700-8525, Japan. kamioka@okayama-u.ac.jp.
Okayama University · JPNikon (Japan) · JPHokkaido University · JPNational Institute for Materials Science · JPNiigata University · JPOkayama University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteocytes form a cellular network by gap junctions between their cell processes. This network is important since intercellular communication via the network is essential for bone metabolism. However, the factors that influence the formation of this osteocyte network remain unknown. As the early stage of osteocyte network formation occurs on the bone surface, we observed a newly formed trabecular bone surface by orthogonal focused ion beam-scanning electron microscopy. The embedding late osteoblast processes tended to avoid bundled collagen fibrils and elongate into sparse collagen fibrils. Then, we examined whether the inhibition of bundling of collagen fibrils using a potent lysyl oxidase inhibitor, β-aminopropionitrile (BAPN) changed the cellular network of the chick calvaria. The osteocyte shape of the control group was spindle-shape, while that of the BAPN group was sphere-shaped. In addition, the osteocyte processes of the control group were elongated vertically to the long axis of the cell body, whereas the osteocyte processes of the BAPN group were elongated radially. Therefore, it was suggested that the bundling of collagen fibrils influences normal osteocyte network formation during bone modeling.

Indexed as

AminopropionitrileOsteocytesCollagenExtracellular MatrixSkullAminopropionitrileCollagen

Identifiers

PMID38086873
PMCPMC10716128
OpenAlexW4389618007

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.