ArticleNature communications2023
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
12.7field-weighted citation impact, top 1% of its field
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Who cites it
46 citing papers in PubMed, 58 citations in OpenAlex.
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- Transcriptomic Analysis and Machine Learning Identify Cross-Pathogen Biomarkers for Bacterial and Parasitic Infections in Silver Pomfret (Animals : an open access journal from MDPI · 2026Article
- Propofol upregulates ANGPTL4 gene and protein expression to inhibit biological behavior of colon cancer cells.Scientific reports · 2026Article
- Sustained-release CGRP microspheres accelerate diabetic wound healing by synergistically promoting neurovascular regeneration through modulation of macrophage and endothelial cell functions.Materials today. Bio · 2026Article
- Celecoxib Inhibits Vasculogenic Mimicry and Induces Apoptosis in the D17 Canine Osteosarcoma Cell Line via the COX-2/PGE2 Signaling Axis.Veterinary sciences · 2026Article
- CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- FOXF2 regulates pericyte-endothelial signaling required for vascular homeostasis after neonatal hyperoxic lung injury.Nature communications · 2026Article
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- Mechanisms and therapeutics of immunometabolic reprogramming driving macrophage-ECs interactions in sepsis-associated ARDS from the gut-lung axis perspective.Frontiers in immunology · 2026Review
- Targeting OxLDL-mediated CD36 + CAF reprogramming potentiates PD-1 immunotherapy in osteosarcoma.Molecular cancer · 2025Article
- FMO2 Promotes Angiogenesis via Regulation of N-Acetylornithine.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Metabolic reprogramming in ischemic stroke: when glycolytic overdrive meets lipid storm.Cell death & disease · 2025Review
- Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases.Journal of advanced research · 2025Review
- Angptl4 is upregulated by microenvironmental factors during the wound healing process and promotes epidermal stem cell proliferation via PRL8a6.Acta biochimica et biophysica Sinica · 2025Article
- Rapid manufacturing of angiogenic cellular collagen patches for ischemic cardiomyopathy.Stem cells translational medicine · 2025Article
- Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention.Journal of the National Cancer Institute · 2025Article
- Endothelial metabolic zonation in the vascular network: a spatiotemporal blueprint for angiogenesis.American journal of physiology. Heart and circulatory physiology · 2025Review
- ANGPTL4: A Comprehensive Review of 25 Years of Research.Cancers · 2025Review
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Authors and funding
12 authors at 1 institution in 1 country.
Balkrishna ChaubeDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4378-7416
Kathryn M CitrinDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Mahnaz SahraeiDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Abhishek K SinghDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Diego Saenz de UrturiDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Wen DingDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.
Richard W PierceVascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5941-8805
Raaisa RaaisaDepartment of Internal Medicine, Yale University, New Haven, CT, USA.
Rebecca CardoneDepartment of Internal Medicine, Yale University, New Haven, CT, USA.
Richard KibbeyYale Center for Molecular and System Metabolism, Yale University School of Medicine, New Haven, CT, USA.
Carlos Fernández-HernandoDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3950-1924
Yajaira SuárezDepartment of Comparative Medicine, Yale University School of Medicine, New Haven, CT, USA. yajaira.suarez@yale.edu.ORCID 0000-0003-4549-2953
Yale University · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MNovel insights into the molecular and cellular mechanism regulating lipid metabolism and atherosclerosisR35HL135820 · NHLBI · YALE UNIVERSITY · PI FERNANDEZ HERNANDO, CARLOS · 2017 to 2023
$6.0MInsights into the molecular mechanisms regulating vascular and immune metabolism in vascular diseasesR35HL155988 · NHLBI · YALE UNIVERSITY · PI Yajaira Suarez · 2021 to 2026
$5.6MMitochondrial ADP privation: A unifying model for glucose-induced insulin secretion.R01DK127637 · NIDDK · YALE UNIVERSITY · PI KIBBEY, RICHARD G, MERRINS, MATTHEW J. · 2021 to 2025
$3.4MMolecular regulation of the capillary barrier in acute critical illnessR01HL170164 · NHLBI · YALE UNIVERSITY · PI RICHARD W PIERCE · 2023 to 2026
$2.3MMechanisms of Endothelial Cell Dysfunction in Critically Ill ChildrenK08HL136898 · NHLBI · YALE UNIVERSITY · PI PIERCE, RICHARD W · 2019 to 2023
$780kDevelopment of an Integrated Intermediary Metabolomics and Metabolic Flux CoreS10OD030370 · OD · YALE UNIVERSITY · PI KIBBEY, RICHARD G · 2022 to 2022
$366kNovel Transcriptional & Post-Transcriptional Regulators of Endothelial Metabolism in AtherosclerosisF31HL156319 · NHLBI · YALE UNIVERSITY · PI CITRIN, KATHRYN · 2022 to 2024
$143kNCATS NIH HHS UL1 TR001863NHLBI NIH HHS F31 HL156319NHLBI NIH HHS K08 HL136898NHLBI NIH HHS R01 HL170164NHLBI NIH HHS R35 HL135820NHLBI NIH HHS R35 HL155988NIDDK NIH HHS R01 DK127637NIH HHS S10 OD030370
Abstract
Angiopoietin-like 4 (ANGPTL4) is known to regulate various cellular and systemic functions. However, its cell-specific role in endothelial cells (ECs) function and metabolic homeostasis remains to be elucidated. Here, using endothelial-specific Angptl4 knock-out mice (Angptl4
Indexed as
AngiogenesisEndothelial CellsAngiopoietin-Like Protein 4AngiopoietinsAnimalsMiceMice, KnockoutAngiopoietin-Like Protein 4AngiopoietinsAngptl4 protein, mouse
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