ArticleNature2024
A molecular switch for neuroprotective astrocyte reactivity.
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Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
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77citing papers in PubMed, 1 pooled it
12.0field-weighted citation impact, top 1% of its field
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Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- A systematic review and meta-analysis on the transcriptomic signatures in alcohol use disorder.Molecular psychiatry · 2025Pooled it
- EGCG-loaded nanoparticles attenuate post-SAH white matter injury by targeting HO-1/S100A10 to suppress oxidative stress-induced reactive astrocytes.Redox report : communications in free radical research · 2026Article
- Glioma microenvironment: Cellular crosstalk, immunosuppression, and novel therapeutic perspectives.Chinese medical journal · 2026Review
- Comparative evaluation of adeno-associated virus and lentivirus mediated gene transfer in adult rat optic nerve.Experimental eye research · 2026Article
- Primary Cilia of Astrocytes in the Retina in Development and Disease.Investigative ophthalmology & visual science · 2026Article
- Ultrashort wave therapy promotes traumatic brain injury recovery by suppressing neuroinflammation.Neural regeneration research · 2026Article
- Smarcc1 drives optic stalk patterning and optic nerve head astrocyte differentiation.Development (Cambridge, England) · 2026Article
- Article
- Astrocytic LMP2 Coordinates NF-κB and TGF-β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- ThebioRxiv : the preprint server for biology · 2026Article
- Role Shift of Glial Cells from Physiology to Pathology in Alzheimer's Disease: The Regulatory Impact of Exercise.Neuroscience bulletin · 2026Review
- Neuroinflammation in glaucoma: a myriad of cellular pathways and players.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Review
- IL-4 in Alzheimer's Disease-Mechanisms and Therapeutic Potential.Molecular neurobiology · 2026Review
- Reactive astrocytes mediate toxicity in iPSC derived dopaminergic neurons.NPJ Parkinson's disease · 2026Article
- SIRT4 Alleviates Retinal Ischemia-Reperfusion Injury Via Mediating Astrocytes Lipid Metabolism and Mitochondrial Function.Investigative ophthalmology & visual science · 2026Article
- Glaucoma and Autoimmunity: Immunopathogenic Mechanisms and Emerging Immunomodulatory Therapies.Biomedicines · 2026Review
- Astrocyte-associated immunosuppressive programs in brain tumors: a STAT3-centered perspective.Cancer metastasis reviews · 2026Review
- Hopx(+) optic nerve head-astrocytes counter neuronal stress and glaucoma damage.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury.CNS neuroscience & therapeutics · 2026Review
- Identification of a Small-Molecule Modulator of Astrocyte Reactivity for Optic Nerve Protection.Investigative ophthalmology & visual science · 2026Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors at 4 institutions in 2 countries.
Evan G Cameron *Mary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA. egcamer1@gmail.com.ORCID 0000-0003-0364-5309
Michael Nahmou *Mary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Anna B Toth *Mary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Lyong HeoStanford Center for Genomics and Personalized Medicine, Stanford University, Palo Alto, CA, USA.
Bogdan TanasaMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Roopa DalalMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Wenjun YanMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.ORCID 0000-0003-3568-4265
Pratima NallagatlaStanford Center for Genomics and Personalized Medicine, Stanford University, Palo Alto, CA, USA.
Xin XiaMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Sarah HayMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Cara KnaselMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Travis L StilesUniversity of California, San Diego, La Jolla, CA, USA.ORCID 0000-0003-4010-7972
Christopher DouglasUniversity of California, San Diego, La Jolla, CA, USA.
Melissa AtkinsMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Catalina SunMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Masoumeh AshouriMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Minjuan BianMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Kun-Che ChangMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.ORCID 0000-0002-0871-5612
Kristina RussanoMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Sahil ShahMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Mollie B WoodworthMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.ORCID 0000-0003-2130-2289
Joana GalvaoMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Ramesh V NairStanford Center for Genomics and Personalized Medicine, Stanford University, Palo Alto, CA, USA.
Michael S KapiloffMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.ORCID 0000-0002-7005-6953
Jeffrey L GoldbergMary M. and Sash A. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA. jlgoldbe@stanford.edu.ORCID 0000-0002-1390-7360
Stanford University · USUniversity of California San Diego · USCardiovascular Institute of the South · USVision Eye Institute · AU
Funding
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI STEPHEN A BACCUS · 2017 to 2026
$8.0MFunction of MEF2 in Neuroprotection and Neuro-regeneration Following StrokeR01EY026766 · NEI · STANFORD UNIVERSITY · PI GOLDBERG, JEFFREY L, KAPILOFF, MICHAEL SETH · 2016 to 2020
$2.4MGene Expression Regulatory Pathways and Retinal Ganglion Cell NeuroprotectionR01EY032416 · NEI · STANFORD UNIVERSITY · PI GOLDBERG, JEFFREY L, KAPILOFF, MICHAEL SETH · 2021 to 2024
$2.2MStanford Vision Training ProgramT32EY027816 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2018 to 2026
$2.0MRole of Soluble Adenylate Cyclase in Reactive AstrocytesF32EY025915 · NEI · STANFORD UNIVERSITY · PI CAMERON, EVAN G · 2015 to 2018
$171kNEI NIH HHS F32 EY025915NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY026766NEI NIH HHS R01 EY032416NEI NIH HHS T32 EY027816
Abstract
The intrinsic mechanisms that regulate neurotoxic versus neuroprotective astrocyte phenotypes and their effects on central nervous system degeneration and repair remain poorly understood. Here we show that injured white matter astrocytes differentiate into two distinct C3-positive and C3-negative reactive populations, previously simplified as neurotoxic (A1) and neuroprotective (A2)
Indexed as
AstrocytesNeuroprotectionAdenylyl CyclasesCell DifferentiationCell NucleusCell SurvivalCyclic AMPCytoplasmGlaucomaMacrophagesMicrogliaOptic Nerve InjuriesRetinal Ganglion CellsWhite MatterAdenylyl CyclasesCyclic AMP
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.