ArticleNature2024
Prevention of respiratory virus transmission by resident memory CD8
Open access · greenAbstract read
In one paragraph
Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 44 citations in OpenAlex.
- Safety and Immunogenicity of aerosolized adenovirus-vectored COVID-19 vaccine and intramuscular mRNA vaccine bivalent boosters: a randomized open-label clinical trial.Nature communications · 2025Trial
- Upper respiratory tract CD8+ tissue-resident memory T cells protect against viral transmission.The Journal of experimental medicine · 2026Article
- Review
- CCR5 blockade inhibits menstrual-driven proinflammatory T cell infiltration into the cervicovaginal mucosa of women.Science advances · 2026Article
- Respiratory mucosal vaccines for emerging viruses: promise and challenges.Journal of virology · 2026Review
- Highly focused human CD8+ T-cell response in the lower airways during acute influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza.The Journal of experimental medicine · 2026Article
- Article
- Quantifying the role of pre-existing tissue resident cellular immunity in limiting respiratory virus transmission.PLoS pathogens · 2026Article
- Antigen specificity, not tissue compartment, determines clonal sharing among respiratory tract CD8Immunology and cell biology · 2026Article
- Intranasal immunization with live-attenuated RSV-vectored SARS-CoV-2 vaccines elicits antigen-specific systemic and mucosal immunity and protects against viral challenge and natural infection.bioRxiv : the preprint server for biology · 2026Article
- Non-cytolytic re-engineering of a viral vaccine vector enables durable effector-memory T cell immunity by reinforcing type I IFN induction.Molecular therapy. Nucleic acids · 2026Article
- Liposomal simvastatin potentiates intranasal H1N1 influenza subunit vaccineActa pharmaceutica Sinica. B · 2026Article
- IFNγ Increases Intracellular Amino Acid Content in Human Alveolar Epithelial Cells: Role of the STAT/IRF1 Axis in the Stimulation of Transmembrane Transport.International journal of molecular sciences · 2026Article
- Duck IFNγ Restricts Duck Tembusu Virus Replication by Disrupting Viral RNA Synthesis/Translation.Veterinary sciences · 2026Article
- Lymph node resident memory T cells retain effector capabilities by evading lung resident memory dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Universal broad-spectrum mucosal vaccine design for human coronaviruses inspired by artificial antibodies.NPJ vaccines · 2026Article
- Differential antiviral effects and immune responses in nasal and airway organoid during RSV infection: implications for interferon therapy.Frontiers in immunology · 2026Article
- Droplet-based single-cell pairing for high-throughput interaction mapping of antigen-receptor combinations.Science advances · 2025Article
- Multivariate Host-Pathogen Interactions Driving Heterogeneous Viral Shedding and CD8medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Ida Uddbäck *Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-6007-5918
Sarah E Michalets *Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Ananya SahaDepartment of Biology, Emory University, Atlanta, GA, USA.
Cameron MattinglyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Kirsten N KostDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
M Elliott WilliamsDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-8271-3394
Laurel A LawrenceDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Sakeenah L HicksDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Anice C LowenDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0002-9829-112X
Hasan AhmedDepartment of Biology, Emory University, Atlanta, GA, USA.
Allan R ThomsenDepartment of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-2392-9803
Charles J RussellDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-5683-3990
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.ORCID 0000-0001-7716-8504
Jeremy M BossDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA.
Katia KoelleDepartment of Biology, Emory University, Atlanta, GA, USA.ORCID 0000-0002-0254-6141
Rustom AntiaDepartment of Biology, Emory University, Atlanta, GA, USA.ORCID 0000-0001-7991-614X
Jan P ChristensenDepartment of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-4299-9479
Jacob E KohlmeierDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, USA. jkohlmeier@emory.edu.ORCID 0000-0002-7209-6641
Emory University · USUniversity of Copenhagen · DKSt. Jude Children's Research Hospital · US
Funding
cGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MCellular and molecular programming of lung resident T cell memoryR35HL150803 · NHLBI · EMORY UNIVERSITY · PI JACOB E KOHLMEIER · 2020 to 2026
$5.4MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MMultiscale modeling of influenza vaccination strategies for optimal T cell immunityU01HL139483 · NHLBI · EMORY UNIVERSITY · PI KOHLMEIER, JACOB E, ZARNITSYNA, VERONIKA I · 2018 to 2022
$3.5MDuration and Function of Lung Tissue Resident CD8+ Memory T cellsF31HL164049 · NHLBI · EMORY UNIVERSITY · PI MATTINGLY, CAMERON · 2023 to 2024
$97kImpact of Resident Memory CD8 T Cells on Respiratory Virus TransmissionF31HL168914 · NHLBI · EMORY UNIVERSITY · PI MICHALETS, SARAH · 2023 to 2024
$71kNHLBI NIH HHS 75N92020D00005NHLBI NIH HHS F31 HL164049NHLBI NIH HHS F31 HL168914NHLBI NIH HHS R35 HL150803NHLBI NIH HHS U01 HL139483NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
Abstract
An ideal vaccine both attenuates virus growth and disease in infected individuals and reduces the spread of infections in the population, thereby generating herd immunity. Although this strategy has proved successful by generating humoral immunity to measles, yellow fever and polio, many respiratory viruses evolve to evade pre-existing antibodies
Indexed as
CD8-Positive T-LymphocytesImmunologic MemoryMemory T CellsParamyxoviridae InfectionsRespiratory SystemAnimalsDisease Models, AnimalEpithelial CellsHumansImmunity, HerdInterferon-gammaMiceParamyxoviridaeTranscription, GeneticIFNG protein, mouseInterferon-gamma
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.