Evidence map›Paper›PMID 38086083›Full record

ArticleBioconjugate chemistry2024

Crossing the Solubility Rubicon: 15-Crown-5 Facilitates the Preparation of Water-Soluble Sulfo-NHS Esters in Organic Solvents.

Nicholas D J Yates, Connor G Miles, Christopher D Spicer, Martin A Fascione, Alison Parkin

Open access · hybridAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicholas D J YatesDepartment of Chemistry, University of York, York, North Yorkshire YO10 5DD, United Kingdom.ORCID 0000-0002-4871-2133
Connor G MilesDepartment of Chemistry, University of York, York, North Yorkshire YO10 5DD, United Kingdom.ORCID 0000-0003-4422-8392
Christopher D SpicerDepartment of Chemistry, University of York, York, North Yorkshire YO10 5DD, United Kingdom.ORCID 0000-0001-8787-578X
Martin A FascioneDepartment of Chemistry, University of York, York, North Yorkshire YO10 5DD, United Kingdom.ORCID 0000-0002-0066-4419
Alison ParkinDepartment of Chemistry, University of York, York, North Yorkshire YO10 5DD, United Kingdom.ORCID 0000-0003-4715-7200
University of York · GB

Funding

Wellcome Trust 225257
6 · The paper itself

Abstract

The Sulfo-NHS ester is a mainstay reagent for facilitating amide bond formation between carboxylic acids and amine functionalities in water. However, the preparation of Sulfo-NHS esters currently requires hydrophobic carboxylic acids, which are poorly water-soluble, to first be reacted with the

Indexed as

Crown EthersEstersSuccinimidesWaterAminesProteinsSodiumSolubilitySolvents15-crown-5AminesCrown EthersEstersN-hydroxysulfosuccimideN-hydroxysulfosuccinimideProteinsSodiumSolventsSuccinimidesWater

Identifiers

PMID38086083
PMCPMC10797585
OpenAlexW4389606882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.