Evidence map›Paper›PMID 38086003›Full record

ArticleJCO oncology practice2024

Cost-Effectiveness Analysis of Screening for Pancreatic Cancer Among High-Risk Populations.

Mary Linton B Peters, Andrew Eckel, Claudia L Seguin, Barak Davidi, David H Howard, Amy B Knudsen, Pari V Pandharipande

Open access · greenAbstract read
In one paragraph

Article in JCO oncology practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Economic evaluations of early detection strategies for pancreatic cancer: a systematic review.The European journal of health economics : HEPAC : health economics in prevention and care · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mary Linton B PetersDivision of Medical Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA.ORCID 0000-0003-0905-7583
Andrew EckelInstitute for Technology Assessment, Massachusetts General Hospital, Boston, MA.ORCID 0000-0002-5263-756X
Claudia L SeguinDepartment of Radiology, The Ohio State University College of Medicine, Columbus, OH.ORCID 0000-0002-1076-5563
Barak DavidiInstitute for Technology Assessment, Massachusetts General Hospital, Boston, MA.
David H HowardDepartment of Health Policy and Management, Rollins School of Public Health, Emory University, Atlanta, GA.ORCID 0000-0002-4465-0414
Amy B KnudsenInstitute for Technology Assessment, Massachusetts General Hospital, Boston, MA.ORCID 0000-0003-1872-996X
Pari V PandharipandeDepartment of Radiology, The Ohio State University College of Medicine, Columbus, OH.
Massachusetts General Hospital · USThe Ohio State University · USBeth Israel Deaconess Medical Center · USEmory University · US

Funding

Precision Management of Cystic Precursors to Pancreatic CancerR01CA237133 · NCI · OHIO STATE UNIVERSITY · PI PANDHARIPANDE, PARI VIJAY · 2019 to 2024
$2.2M
Cost Effectiveness of Germline Genetic Testing in Pancreatic CancerK08CA248473 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI PETERS, MARY LINTON B · 2020 to 2024
$1.3M
NCI NIH HHS K08 CA248473NCI NIH HHS R01 CA237133
6 · The paper itself

Abstract

purposeWe evaluated the potential cost-effectiveness of combined magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) screening for pancreatic ductal adenocarcinoma (PDAC) among populations at high risk for the disease.

methodsWe used a microsimulation model of the natural history of PDAC to estimate the lifetime health benefits, costs, and cost-effectiveness of PDAC screening among populations with specific genetic risk factors for PDAC, including

resultsFor men with relative risk (RR) 12.33 (

conclusionCombined MRI/EUS screening may be a cost-effective approach for the highest-risk populations (among mutations considered, those with RR >12). However, for those with moderate risk (RR, 5-12), screening would only be cost-effective at higher WTP thresholds (eg, $200K USD/QALY) or with once-only screening.

Indexed as

Cost-Effectiveness AnalysisPancreatic NeoplasmsAgedCost-Benefit AnalysisEarly Detection of CancerFemaleHumansMedicareMiddle AgedRisk FactorsUnited States

Identifiers

PMID38086003
PMCPMC10911581
OpenAlexW4389608301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.