Evidence map›Paper›PMID 38085649›Full record

ArticleAging2023

Rewiring of IGF1 secretion and enhanced IGF1R signaling induced by co-chaperone carboxyl-terminus of Hsp70 interacting protein in adipose-derived stem cells provide augmented cardioprotection in aging-hypertensive rats.

Parthasarathi Barik, Wei-Wen Kuo, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Cecilia Hsuan Day, Jayasimharayalu Daddam, Michael Yu-Chih Chen, V Vijaya Padma, Marthandam Asokan Shibu, Chih-Yang Huang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Cellular and molecular mechanisms underlying cardiovascular aging.Cellular & molecular biology letters · 2025
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Parthasarathi BarikGraduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, Taichung, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Dennis Jine-Yuan HsiehSchool of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Cecilia Hsuan DayDepartment of Nursing, Mei Ho University, Pingtung, Taiwan.
Jayasimharayalu DaddamCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Michael Yu-Chih ChenDepartment of Cardiology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
V Vijaya PadmaDepartment of Biotechnology, Bharathiar University, Coimbatore, India.
Marthandam Asokan ShibuDepartment of Biotechnology, Bharathiar University, Coimbatore, India.
Chih-Yang HuangGraduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan.
Bharathiar University · INChina Medical University · TWAsia University · TWBuddhist Tzu Chi General Hospital · TWChung Shan Medical University Hospital · TWMeiho University · TWTzu Chi Foundation · TWUniversity of Taipei · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging-associated cardiovascular diseases depend on the longitudinal deterioration of stem cell dynamics. The entire mechanism behind it is not completely understood. However, many studies suggest that endocrine pathways, particularly the insulin-like growth factor-1(IGF1) signaling pathway are involved in cardioprotection, especially in stem-cell treatments. Here, we investigated the role of a co-chaperone, carboxyl-terminus of Hsp70 interacting protein (CHIP) in the aspects of growth factor secretion and receptor stabilization in mesenchymal stem cells (MSCs). Briefly, we overexpressed CHIP in rat adipose-derived stem cells (rADSCs) and explored the consequences

Indexed as

HypertensionReceptor, IGF Type 1AdipocytesAgingAnimalsInsulin-Like Growth Factor IRatsSignal TransductionStem CellsUbiquitin-Protein LigasesInsulin-Like Growth Factor IReceptor, IGF Type 1Stub1 protein, ratUbiquitin-Protein Ligasesadipose-derived stem cellsagingcardiovascular diseasesco-chaperone CHIPhypertensioninsulin-like growth factor-1 (receptor) – IGF1(R)

Identifiers

PMID38085649
PMCPMC10756089
OpenAlexW4389548579

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.