Evidence map›Paper›PMID 38085501›Full record

SynthesisIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2024

Sarcopenia is a risk factor for post-transjugular intrahepatic portosystemic shunt hepatic encephalopathy and mortality: A systematic review and meta-analysis.

Zohaib Ahmed, Joyce Badal, Manesh Kumar Gangwani, Ahmad Nawaz, Bryan Badal, Syeda Faiza Arif, Umer Farooq, Faisal Kamal, Toseef Javaid, Muhammad Aziz and 6 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. [Assessment and management of malnutrition in patients with cirrhosis combined with hepatic encephalopathy].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 7 institutions in 2 countries.

Zohaib AhmedDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA.
Joyce BadalUniversity of Toledo College of Medicine and Life Sciences, Toledo, OH, USA.
Manesh Kumar GangwaniDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA. Gangwani.manesh@gmail.com.ORCID 0000-0002-3931-6163
Ahmad NawazDepartment of Internal Medicine, Yale-New Haven Hospital, New Haven, CT, USA.
Bryan BadalDepartment of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University and Richmond VA Medical Center, Richmond, VA, USA.
Syeda Faiza ArifDow University of Health Sciences, Karachi, Pakistan.
Umer FarooqDepartment of Internal Medicine, Loyola Medicine/MacNeal Hospital, Chicago, IL, USA.
Faisal KamalDepartment of Gastroenterology, University of California, Los Angeles, Los Angeles, CA, USA.
Toseef JavaidDepartment of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.
Muhammad AzizDepartment of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.
Wade Lee-SmithUniversity of Toledo Libraries, University of Toledo, Toledo, OH, USA.
Asif MahmoodDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA.
Nooraldin MerzaDepartment of Internal Medicine, University of Toledo, Toledo, OH, USA.
Abdallah KobeissyDepartment of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.
Ali NawrasDepartment of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.
Mona HassanDepartment of Gastroenterology and Hepatology, University of Toledo, Toledo, OH, USA.
University of Toledo · USDow University of Health Sciences · PKHunter Holmes McGuire VA Medical Center · USMacNeal Hospital · USUniversity of California, Los Angeles · USUniversity of North Carolina at Chapel Hill · USYale New Haven Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsTransjugular intrahepatic portosystemic shunt (TIPS) is a commonly performed procedure in patients with liver cirrhosis to treat portal hypertension-related conditions, including variceal bleeding and refractory ascites. However, while the increased risk of hepatic encephalopathy (HE) after TIPS is important to consider when determining whether a patient is a good candidate for TIPS, currently there is no widely used method to predict the development of post-TIPS HE, although the model for end-stage liver disease (MELD) score is used to predict post-TIPS mortality. We conducted a systematic review and meta-analysis to evaluate sarcopenia as a risk factor for HE and mortality in patients undergoing TIPS.

methodsA comprehensive search strategy was used to identify reports of post-TIPS HE and mortality in sarcopenia vs. non-sarcopenia patients with liver cirrhosis who received TIPS in March 2023. Open Meta Analyst was used to compute the results.

resultsTwelve studies with 2056 patients met inclusion criteria and were included in the final meta-analysis. Sarcopenia was associated with a significantly higher post-TIPS HE rate than non-sarcopenia (risk ratio [RR]: 1.68, 95% CI: 1.48-1.92, p < 0.00001, I

conclusionPatients with sarcopenia have a significantly increased risk of post-TIPS HE and mortality. Presence of sarcopenia should be considered when weighing the risks and benefits of performing TIPS in patients with cirrhosis. Further studies are needed to determine the clinical utility of important risk factors such as sarcopenia on post-TIPS outcomes.

Indexed as

Hepatic EncephalopathyLiver CirrhosisPortasystemic Shunt, Transjugular IntrahepaticSarcopeniaHumansHypertension, PortalMalePostoperative ComplicationsRisk FactorsLiver encephalopathyMeta-analysisMuscle atrophyMuscle wastingPortocaval shuntRefractory ascitesSarcopeniaSystematic reviewTIPSTransjugular intrahepatic portacaval shuntTransjugular intrahepatic portosystemic shuntVariceal bleeding

Identifiers

PMID38085501
OpenAlexW4389608963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.