Evidence map›Paper›PMID 38085396›Full record

ArticleBulletin of experimental biology and medicine2023

Polymorphisms of the NCF4 Gene Increase the Risk of Chronic Heart Failure in Patients with Type 2 Diabetes Mellitus.

Yu E Azarova, E Yu Klyosova, V E Ivakin, M I Churilin, I I Kolomoets, O A Sunyaykina, V A Ragulina, A V Polonikov

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In one paragraph

Article in Bulletin of experimental biology and medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yu E AzarovaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia. azzzzar@yandex.ru.
E Yu KlyosovaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
V E IvakinKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
M I ChurilinKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
I I KolomoetsKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
O A SunyaykinaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
V A RagulinaKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
A V PolonikovKursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia.
Ministry of Health of the Russian Federation · RUKursk State Medical University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We showed for the first time that polymorphisms rs2075938 and rs2075938 of the NCF4 gene are associated with the risk of chronic heart failure in patients with type 2 diabetes mellitus (n=1310). In particular, haplotypes ATGTCTAT (OR=1.74, 95%CI=1.23-2.47; p=0.0017) and ATATTCAC (OR=2.83, 95%CI=1.33-6.03; p=0.0072) of NCF4 increase the risk of chronic heart failure in type 2 diabetes mellitus patients. The results show that NADPH oxidase subunit NCF4 is involved in the molecular mechanisms of myocardial damage in type 2 diabetes mellitus.

Indexed as

Diabetes Mellitus, Type 2Heart FailureGenetic Predisposition to DiseaseHaplotypesHumansNADPH OxidasesPolymorphism, Single NucleotideNADPH OxidasesNCF4 protein, humanchronic heart failuregenetic predispositionNCF4single nucleotide polymorphismtype 2 diabetes mellitus

Identifiers

PMID38085396
OpenAlexW4389613967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.