← Metformin × pregnancy & neonatal

TrialJAMA2023

Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Early Pregnancy: The MOMPOD Randomized Clinical Trial.

Kim A Boggess et al.PubMed ↗Full text ↗Publisher ↗

The primary results report of NCT02932475. Its numbers are set against the trial’s posted results below.

What the trial testedrandomised · 831 people · 2023

Randomised comparison

Probably lowered pregnancy & neonatal

−37%−54% to −14%

Bigger than 7 in 10 on the map

As reported

OR 0.63, 95% CI 0.46–0.86

Range includes no effect

No clear effect on adverse events & safety

Doesn’t vote: same as the registry's posted result, which counts instead

−14%−37% to +19%

Bigger than 4 in 10 for adverse events & safety

As reported

OR 0.86, 95% CI 0.63–1.19

Against the trial’s posted results

  • Same as the trial’s posted resultThis paper OR 0.86 (0.63–1.19)Posted, primary outcome OR 0.86 (0.63–1.19)Number of Participants With Composite Adverse Neonatal Outcome

Two numbers in the abstract

the abstract, start to end

… the placebo group (adjusted odds ratio, 0.86 [95% CI 0.63-1.19]).

… gestational age (adjusted odds ratio, 0.63 [95% CI, 0.46-0.86]) when …

← favours treatmentfavours comparator →
could be chance
Adverse events & safety
OR 0.860.63–1.19
Pregnancy & neonatal
OR 0.630.46–0.86
MetforminPregnancy & neonatalAdverse events & safety

Metformin × pregnancy & neonatalhelps?mixed

unlikelylikely
0.000.25 without it
← favours treatmentfavours comparator →
this papermore certainless certain
1 / 6

38 papers cite it

2023
2024
2025
2026
this paperpooled ittrialcites it

The trial

NCT02932475phase 3831 enrolled2017this paper is its primary report
Full record →Abstract, authors, funding and every citing paper · PMID 38085312