ArticleDiabetologia2024
Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease.
Article in Diabetologia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 21 citations in OpenAlex.
- Type 2 diabetes prevention across the life course.Nature medicine · 2026Review
- Gut Microbiome-Hormone Interactions and Precision Fermentation in the Prevention of Early Cardiovascular Risk in Adolescents.International journal of molecular sciences · 2026Review
- Life-course body size trajectories and the progression of cardio-renal-metabolic multimorbidity: a prospective UK biobank study.Nutrition & metabolism · 2026Article
- Adipose cellularity and long-term development of impaired glucose metabolism: Swedish cohort study from 1988 through 2016.EBioMedicine · 2026Article
- Childhood Obesity: Global Burden, Multifactorial Etiologies, Biological Mechanisms, and Emerging Interventions for Prevention and Management.Saudi medical journal · 2026Review
- Serum uric acid/creatinine ratio and metabolic-associated fatty liver disease risks in children.Pediatric research · 2026Article
- Inflammatory mediation of aerobic, resistance, and combined exercise effects on the vascular elasticity of obese women.iScience · 2026Article
- The association between childhood body size, adulthood lifestyle, and risk of 50 health conditions.Communications medicine · 2026Article
- Child-To-Adult Body Size Change and Risk of Depression and Anxiety: A Large Prospective Cohort Study.Depression and anxiety · 2026Article
- Letter: Separating the Effects of Early-Life and Adult Body Size on Chronic Kidney Disease Risk: A Mendelian Randomization Study (J Obes Metab Syndr 2025;34:65-74).Journal of obesity & metabolic syndrome · 2025Article
- Associations of child-to-adult body size change with risk of hypertension and metabolic dysfunction-associated steatotic liver disease: a population-based cohort study of 226,420 individuals.BMC public health · 2025Article
- Relationship Between Oxidative Stress and Cardiovascular Risk in Adolescents in Montenegro.International journal of molecular sciences · 2025Article
- Childhood obesity directly increases age-related macular degeneration risk: the role of physiobiological and immune-metabolic function.Journal of global health · 2025Article
- Are associations of adulthood overweight and obesity with all-cause mortality, cardiovascular disease, and obesity-related cancer modified by comparative body weight at age 10 years in the UK Biobank study?International journal of obesity (2005) · 2025Article
- Evaluating the Role of School-Based Physical Activity in Mitigating Cardiometabolic Risk Factors in Children and Adolescents with Overweight or Obesity: A Systematic Review and Meta-Analysis.Children (Basel, Switzerland) · 2025Review
- Classification and identification of risk factors for type 2 diabetes.World journal of diabetes · 2025Review
- Machine Learning-Based predictive model for adolescent metabolic syndrome: Utilizing data from NHANES 2007-2016.Scientific reports · 2025Article
- Article
- Association of childhood-adulthood body size trajectories with risk of micro- and macrovascular complications among individuals with type 2 diabetes: a prospective study.Diabetology & metabolic syndrome · 2024Article
- The Association of Weight Categories in Adolescence with Cardiovascular Morbidity in Young Adult Israeli Arabs-A Nationwide Study.Journal of clinical medicine · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
aims/hypothesisChildhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of childhood leanness on adult obesity and disease risk has been overlooked. We examined the independent and combined influences of child and adult body size on the risk of type 2 diabetes and cardiovascular disease.
methodsData from the UK Biobank on 364,695 individuals of European ancestry and free of type 2 diabetes and cardiovascular disease were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. After a median follow-up of 12.8 years, 33,460 individuals had developed type 2 diabetes and/or cardiovascular disease. We used Cox regression models to assess the associations of body size categories with disease incidence.
resultsIndividuals with low body size in childhood and high body size in adulthood had the highest risk of type 2 diabetes (HR 4.73; 95% CI 4.50, 4.99), compared to those with average body size in both childhood and adulthood. This was significantly higher than the risk in those with high body size in both childhood and adulthood (HR 4.05; 95% CI 3.84, 4.26). By contrast, cardiovascular disease risk was determined by adult body size, irrespective of childhood body size. CONCLUSIONS/
interpretationLow body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial.
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Registered trials
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