Evidence map›Paper›PMID 38084427›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2024

Molecular mechanisms underlying TNFα-induced mitochondrial fragmentation in human airway smooth muscle cells.

Debanjali Dasgupta, Sanjana Mahadev Bhat, Claire Creighton, Catherin Cortes, Philippe Delmotte, Gary C Sieck

Abstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Molecular mechanisms underlying FCCP-induced mitophagy in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  3. Article
  4. Review
  5. AhR activation inhibits DRP1-induced mitochondrial fission in airway smooth muscle during asthma.American journal of respiratory cell and molecular biology · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Tumor necrosis factor α-induced endoplasmic reticulum stress promotes airway smooth muscle cell proliferation.American journal of physiology. Lung cellular and molecular physiology · 2026
    Article
  10. Review
  11. TNFα-mediated subcellular heterogeneity of succinate dehydrogenase activity in human airway smooth muscle cells.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Debanjali DasguptaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-8307-9719
Sanjana Mahadev BhatDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-7597-9597
Claire CreightonDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.
Catherin CortesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.
Philippe DelmotteDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-1285-6554
Gary C SieckDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0003-3040-9424

Funding

Impact of Airway Inflammation on MitochondriaR01HL157984 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2021 to 2024
$2.7M
Role of Mitochondria in Airway Smooth MuscleR01HL126451 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S., SIECK, GARY C. · 2015 to 2018
$1.9M
NHLBI NIH HHS R01 HL126451NHLBI NIH HHS R01 HL157984
6 · The paper itself

Abstract

Tumor necrosis factor α (TNFα), a proinflammatory cytokine, plays a significant role in mediating the effects of acute inflammation in response to allergens, pollutants, and respiratory infections. Previously, we showed that acute exposure to TNFα induces mitochondrial fragmentation in human airway smooth muscle (hASM) cells, which is associated with increased expression of dynamin-related protein 1 (DRP1). Phosphorylation of DRP1 at serine 616 (pDRP1

Indexed as

CytokinesTumor Necrosis Factor-alphaHumansInflammationMyocytes, Smooth MusclePhosphorylationSerineCytokinesSerineTumor Necrosis Factor-alphaairway inflammationairway smooth muscleDRP1 phosphorylationER stressmitochondrial fragmentation

Identifiers

PMID38084427
PMCPMC11280718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.