ReviewFrontiers in endocrinology2023
The effects of peripheral hormone responses to exercise on adult hippocampal neurogenesis.
Review in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nonlinear dose-response effects of exercise interventions on post-stroke depression: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Effects of Individualized High-Intensity Online Concurrent Exercise Guided by Autonomic Modulation on the Mental Health and Quality of Life of Breast Cancer Survivors.Psycho-oncology · 2025Trial
- Physical Activity and Purkinje Cells: Mechanisms of Cerebellar Plasticity and Neuroprotection.Journal of functional morphology and kinesiology · 2026Review
- Role of 5-hydroxytryptamine type 3 receptors in aerobic exercise-induced improvement of memory and hippocampal synaptic plasticity.Neural regeneration research · 2026Article
- The Dual Role of VEGF in Intracerebral Haemorrhage: From Pathological Mechanisms to Therapeutic Opportunities.Revista de neurologia · 2026Review
- Voluntary running exercise is associated with metabolic shifts linked to adult hippocampal neurogenesis.Scientific reports · 2026Article
- The association between domain-specific physical activity in adults and Parkinson's disease and all-cause mortality: a NHANES study from 2007 to 2018.Biology of sport · 2026Article
- Physical exercise/melatonin interaction in young rats fed a low-protein diet: a behavioral, electrophysiological, and redox balance analysis.Frontiers in aging neuroscience · 2026Article
- The neuro-immuno-metabolic axis of exercise: a unified mechanistic framework for exercise-induced cognitive enhancement and psychological resilience.Frontiers in psychology · 2026Review
- Neuroprotective cellular and molecular mechanisms of physical exercise on neurodegenerative diseases.ADMET & DMPK · 2026Review
- Research advances on estrogen deficiency leading to depression.Translational neuroscience · 2026Review
- Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease.Cells · 2025Review
- CoQ10-Supported HIIT Modulates Skeletal Muscle and Hippocampal Biomarkers in Rats: A Randomized, Repeated-Measures, Post-Test Controlled Design.Antioxidants (Basel, Switzerland) · 2025Article
- Role of RNA-binding proteins in exercise-induced mRNA regulation: Unveiling biomarkers and therapeutic targets for schizophrenia.World journal of psychiatry · 2025Review
- Exercise orchestrates systemic metabolic and neuroimmune homeostasis via the brain-muscle-liver axis to slow down aging and neurodegeneration: a narrative review.European journal of medical research · 2025Review
- Aerobic exercise training improves learning and memory performance in hypoxic-exposed rats by activating the hippocampal PKA-CREB-BDNF signaling pathway.BMC neuroscience · 2025Article
- Comparative effects of single-task and dual-task acute moderate-intensity exercise on cortisol and cognitive performance.Frontiers in psychology · 2025Article
- Hippocampal Neurogenesis via Light-Intensity Running and Its Mechanism.Advances in neurobiology · 2025Review
- Irisin in Reproduction: Its Roles and Therapeutic Potential in Male and Female Fertility Disorders.Biomolecules · 2024Review
- Proneurogenic actions of follicle-stimulating hormone on neurospheres derived from ovarian cortical cells in vitro.BMC veterinary research · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Over the last decade, a considerable amount of new data have revealed the beneficial effects of exercise on hippocampal neurogenesis and the maintenance or improvement of cognitive function. Investigations with animal models, as well as human studies, have yielded novel understanding of the mechanisms through which endocrine signaling can stimulate neurogenesis, as well as the effects of exercise on acute and/or chronic levels of these circulating hormones. Considering the effects of aging on the decline of specific endocrine factors that affect brain health, insights in this area of research are particularly important. In this review, we discuss how different forms of exercise influence the peripheral production of specific endocrine factors, with particular emphasis on brain-derived neurotrophic factor, growth hormone, insulin-like growth factor-1, ghrelin, estrogen, testosterone, irisin, vascular endothelial growth factor, erythropoietin, and cortisol. We also describe mechanisms through which these endocrine responses to exercise induce cellular changes that increase hippocampal neurogenesis and improve cognitive function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.