Evidence map›Paper›PMID 38084103›Full record

ArticleJournal of inflammation research2023

Indole-3-Aldehyde Reduces Inflammatory Responses and Restores Intestinal Epithelial Barrier Function Partially via Aryl Hydrocarbon Receptor (AhR) in Experimental Colitis Models.

Mu Wang, Jian Guo, Ailsa L Hart, Jia V Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of inflammation research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Mu Wang *Section of Nutrition, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.ORCID 0000-0002-5094-1672
Jian Guo *Department of General Surgery, Shanxi Provincial People's Hospital, the Affiliated People's Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, 030012, People's Republic of China.
Ailsa L HartIBD Unit, St. Mark's Hospital, London, HA1 3UJ, UK.
Jia V LiSection of Nutrition, Division of Digestive Diseases, Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, W12 0NN, UK.
Shanxi Medical University · CNImperial College London · GBSt Mark's Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Indole-3-aldehyde (IAld) has been shown to improve intestinal epithelial barrier (IEB) function through the aryl hydrocarbon receptor (AhR) in murine colitis models. However, the impact of IAld on intestinal tissue inflammation remains unexplored. This study aimed to investigate the effects of IAld on the inflammatory responses of the gut both in vivo and in vitro and probe the mechanisms by which IAld attenuates colitis. Methods: The effects of IAld on phenotypic changes, pro-inflammatory cytokines, IEB functions and the faecal bacterial composition in mice with dextran sulfate sodium salt (DSS)-induced colitis were assessed. Macrophage cells and intestinal epithelial cells were stimulated with lipopolysaccharide (LPS), and the effects of IAld on the inflammatory responses and IBE functions were measured. Results: IAld reduced IL-6, IL-1β and TNF-α protein levels in both colonic tissues from the mice with colitis and LPS-stimulated macrophage cells. The IAld-mediated reduction of IL-6 but not IL-1β and TNF-α was through AhR activation. Furthermore, nuclear factor-κB pathway was found to be inhibited by IAld treatment via AhR activation both in vivo and in vitro. Gut permeability was significantly improved by IAld in both DSS-treated mice and LPS-stimulated Caco-2 cells. This observation is consistent with downregulation of phosphorylated myosin light chain through AhR activation. IAld did not appear to have an effect on the bacterial composition in mice with colitis despite the reduced colonic inflammatory responses. Conclusion: IAld improved DSS-induced colitis by inhibiting the inflammatory responses and restoring IEB function, partially via AhR activation. This work provided insight into the function of IAld in modulating gut inflammation.

Indexed as

indole-3-aldehyde aryl hydrocarbon receptor intestinal inflammation

Identifiers

PMID38084103
PMCPMC10710743
OpenAlexW4389338158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.