Evidence map›Paper›PMID 38084047›Full record

ArticleJournal of clinical research in pediatric endocrinology2026

Atypical Presentation and Course of ACTH-Independent Cushing’s Syndrome in Two Families

Kübra Yüksek Acınıklı, Sezer Acar, Ahu Paketçi, Özgür Kırbıyık, Mert Erbaş, Özge Besci, Gözde Akın Kağızmanlı, Deniz Kızmazoğlu, Oktay Ulusoy, Erdener Özer and 5 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of clinical research in pediatric endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 4 countries.

Kübra Yüksek AcınıklıDokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, TürkiyeORCID 0000-0001-9492-4834
Sezer AcarManisa City Hospital, Clinic of Pediatric Endocrinology, Manisa, TürkiyeORCID 0000-0001-8048-8066
Ahu PaketçiMedipol Mega University Hospital, Department of Pediatric Endocrinology, İstanbul, Türkiye
Özgür KırbıyıkUniversity of Health Sciences Türkiye, İzmir Tepecik Training and Research Hospital, Genetic Diagnosis Center, İzmir, TürkiyeORCID 0000-0003-1333-2007
Mert ErbaşUniversity of Health Sciences Türkiye, Dr. Behçet Uz Pediatric Diseases and Surgery Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, TürkiyeORCID 0000-0001-9368-8868
Özge BesciDokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, TürkiyeORCID 0000-0003-3135-9617
Gözde Akın KağızmanlıDokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, TürkiyeORCID 0000-0002-6158-9002
Deniz KızmazoğluDokuz Eylül University Institute of Oncology, Department of Pediatric Oncology, İzmir, TürkiyeORCID 0000-0003-3349-7140
Oktay UlusoyDokuz Eylül University Faculty of Medicine, Department of Pediatric Surgery, İzmir, TürkiyeORCID 0000-0002-0992-8724
Erdener ÖzerDokuz Eylül University Faculty of Medicine, Department of Pathology, İzmir, TürkiyeORCID 0000-0001-5743-5222
Kutsal YörükoğluDokuz Eylül University Faculty of Medicine, Department of Pathology, İzmir, TürkiyeORCID 0000-0002-4099-0905
Ayhan AbacıDokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, TürkiyeORCID 0000-0002-1812-0321
Handan GüleryüzDokuz Eylül University Faculty of Medicine, Department of Radiology, Division of Pediatric Radiology, İzmir, TürkiyeORCID 0000-0003-1691-1362
Ece BöberDokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, TürkiyeORCID 0000-0001-8828-0892
Korcan DemirDokuz Eylül University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, TürkiyeORCID 0000-0002-8334-2422
Dokuz Eylül University · TRIzmir University · TRIstanbul Medipol University · TRNara City Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare genetic disease mainly associated with Carney complex (CNC), which is caused by germline mutations of the regulatory subunit type I-alpha of the cAMP-dependent protein kinase (

Indexed as

Adrenal Cortex DiseasesCarney ComplexCushing SyndromeCyclic AMP-Dependent Protein Kinase RIalpha SubunitAdolescentAdrenalectomyAdrenocorticotropic HormoneAdultChildFemaleHumansMalePedigreeAdrenocorticotropic HormoneCyclic AMP-Dependent Protein Kinase RIalpha SubunitPRKAR1A protein, humancancerCushing’s diseaselentigomacronodulemyxomaPEG precipitation

Identifiers

PMID38084047
PMCPMC12989889
OpenAlexW4389623210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.