ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
A Novel Cargo Delivery System-AnCar-Exo
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Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Immunometabolism of macrophages in the bone microenvironment: a new perspective for bone healing therapy.Journal of advanced research · 2026Review
- Synovial inflammatory macrophage-derived extracellular vesicles exacerbate cartilage lesions with a FMRP-selectively sorted manner in osteoarthritis.Bone research · 2026Article
- Engineered Spirulina platensis for treating rheumatoid arthritis and restoring bone homeostasis.Nature communications · 2025Article
- A Novel Cargo Delivery System-AnCar-ExoAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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Authors and funding
34 authors at 3 institutions in 1 country.
Song LiCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.ORCID 0000-0002-9086-4309
Ya-Ran WuDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, 40000, China.
Xiu-Qin PengCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Han-Gang ChenCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Tong-Yi ZhangState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Hua ChenCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Jing YangCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Yang-Li XieCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Hua-Bing QiCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Wei XiangState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Bo HuangState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Si-Ru ZhouCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Yan HuDepartment of Military Basic Training and Army Management, Army Health Service Training Base, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Qiao-Yan TanCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Xiao-Lan DuCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Jun-Lan HuangCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Ruo-Bin ZhangCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Xiao-Hong LiCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Feng-Tao LuoCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Min JinCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Nan SuCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Xiao-Qing LuoCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Shuo HuangCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Peng YangCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Xiao-Jing YanDepartment of Biochemistry and Molecular Biology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Ji-Qin LianDepartment of Clinical Biochemistry, Faculty of Pharmacy and Laboratory Medicine, Army Medical University (Third Military Medical University), Chongqing, 40000, China.
Ying ZhuDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, China.
Yan XiongCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Gong-Yi XiaoCenter for Joint Surgery, Department of Orthopedic Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, China.
Ying-Ying LiuCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Chen ShenCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Liang KuangCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Zhen-Hong NiState Key Laboratory of Trauma, Burns and Combined Injury, Department of Rehabilitation Medicine, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Lin ChenCenter of Bone Metabolism and repair, laboratory for Prevention and rehabilitation of Training injuries, State Key laboratory of Trauma, Burns and combined injury, Trauma center, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400000, China.
Army Medical University · CNDalian Medical University · CNThe Affiliated Yongchuan Hospital of Chongqing Medical University · CN
Funding
army medical university project 2021XQN22General Project of Chongqing Natural Science Foundation cstc2020jcyj-msxmX0112National Key Research and Development Program of China 2018YFA0800802National Natural Science Foundation of China 81830075National Natural Science Foundation of China 81871817National Natural Science Foundation of China 82202770National Natural Science Foundation of China 82372495National Natural Science Youth Foundation of China 82002360Natural Science Foundation of Chongqing CSTB2022NSCQ-MSX1267
Abstract
Macrophages are heterogenic phagocytic cells that play distinct roles in physiological and pathological processes. Targeting different types of macrophages has shown potent therapeutic effects in many diseases. Although many approaches are developed to target anti-inflammatory macrophages, there are few researches on targeting pro-inflammatory macrophages, which is partially attributed to their non-s pecificity phagocytosis of extracellular substances. In this study, a novel recombinant protein is constructed that can be anchored on an exosome membrane with the purpose of targeting pro-inflammatory macrophages via antigen recognition, which is named AnCar-Exo
Indexed as
ArthritisMacrophagesAnti-Inflammatory AgentsCell CommunicationHumansPhagocytosisAnti-Inflammatory AgentsarthritisexosomeHIF-1α
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.