ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2023
The Significance of Concentration-dependent Components in Computational Models of C-Fibers.
Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
- Temporal properties of direct current sensory block of the rat sciatic nerve using the C-fiber reflex.Journal of neural engineering · 2025Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Computational models of neurons are valuable tools that allow researchers to form and evaluate hypotheses and minimize high-cost animal work. We soon plan to use computational modeling to explore the response of different sensory fiber types to long duration external stimulation to try to selectively block nociceptive C-fibers. In this work, we modified an existing C-fiber-specific axon model to additionally include concentration-dependent conductance changes, the contribution of longitudinal current flow to changes in local concentrations, and longitudinal currents generated by concentration gradients along the axon. Then, we examined the impact of these additional elements on the modeled action potential properties, activity-dependent latency increases, and concentration changes due to external stimulation. We found that these additional model elements did not significantly affect the action potential properties or activity-dependent behavior, but they did have a significant impact on the modeled response to external long duration stimulation.Clinical Relevance- This presents a computational model that can be used to help investigate and develop electrical stimulation therapies for pathological pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.