ReviewJournal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale2023
Redox homeostasis dysregulation in noise-induced hearing loss: oxidative stress and antioxidant treatment.
Review in Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 23 citations in OpenAlex.
- Hydrogen: a novel strategy for preventing and treating hearing loss.Medical gas research · 2026Review
- Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS-Initiated Neuroinflammation and BK Channel Suppression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Paeonol Alleviate Cisplatin- and Noise-Induced Hearing Loss by Preserving Hair Cell Ribosome Biogenesis.CNS neuroscience & therapeutics · 2026Article
- The Glutamate-Glutathione axis in neuropsychiatric disorders and cancer: From shared mechanisms to non-invasive biomarkers.Redox biology · 2026Review
- Effect of acetylsalicylic acid (ASA) pretreatment on white noise-induced stress model in rats.BMC veterinary research · 2026Article
- Remnant cholesterol and auditory outcomes in NHANES 1999-2016: associations with frequency-range hearing loss and tinnitus.Lipids in health and disease · 2026Article
- Is Macular Telangiectasia Type 2 Associated with Hearing Loss and Cochlear Dysfunction? A Prospective Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives.Journal of xenobiotics · 2026Review
- Effects of mixed blood metals on hearing loss among steel workers: a case-control study.Frontiers in public health · 2026Article
- Revealing intracochlear microtrauma during cochlear implantation using optical coherence tomography and electrochemical sensing.Scientific reports · 2025Article
- Liquid-Liquid Phase Separation in Hereditary Hearing Loss.Neuroscience bulletin · 2025Review
- AIMP1 exerts hearing protection role in age related hearing loss mice by regulating SIRT1 expression.BMC geriatrics · 2025Article
- Article
- Physical rehabilitation for sensorineural hearing loss in childhood: Progress and challenges.World journal of clinical cases · 2025Article
- Association of serum lycopene with low-frequency hearing loss in adults in their 70s based on NHANES database.Scientific reports · 2025Article
- Exploring biomarkers for noise-induced hearing loss through mitochondrial DNA methylation analysis.Frontiers in pharmacology · 2025Article
- SOD mediates mitochondrial epigenetic regulation in NIHL.Frontiers in cellular neuroscience · 2025Article
- A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment.Antioxidants (Basel, Switzerland) · 2024Review
- Occupational epidemiological characteristics of noise-induced hearing loss and the impact of combined exposure to noise and dust on workers' hearing-a retrospective study.Frontiers in public health · 2024Article
- Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
Abstract
Noise exposure is an important cause of acquired hearing loss. Studies have found that noise exposure causes dysregulated redox homeostasis in cochlear tissue, which has been recognized as a signature feature of hearing loss. Oxidative stress plays a pivotal role in many diseases via very complex and diverse mechanisms and targets. Reactive oxygen species are products of oxidative stress that exert toxic effects on a variety of physiological activities and are considered significant in noise-induced hearing loss (NIHL). Endogenous cellular antioxidants can directly or indirectly counteract oxidative stress and regulate intracellular redox homeostasis, and exogenous antioxidants can complement and enhance this effect. Therefore, antioxidant therapy is considered a promising direction for NIHL treatment. However, drug experiments have been limited to animal models of NIHL, and these experiments and related observations are difficult to translate in humans; therefore, the mechanisms and true effects of these drugs need to be further analyzed. This review outlines the effects of oxidative stress in NIHL and discusses the main mechanisms and strategies of antioxidant treatment for NIHL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.