Evidence map›Paper›PMID 38082290›Full record

ArticleJournal of translational medicine2023

The preprogrammed anti-inflammatory phenotypes of CD11c

Shifei Yao, Danlin Weng, Yan Wang, Yanyu Zhang, Qi Huang, Kaifeng Wu, Honghui Li, Xuemei Zhang, Yibing Yin, Wenchun Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Shifei YaoKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Danlin WengKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Yan WangKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Yanyu ZhangKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Qi HuangKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Kaifeng WuDepartment of Laboratory Medicine, The First People's Hospital of Zunyi City (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, 563000, China.
Honghui LiKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Xuemei ZhangKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Yibing YinKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Wenchun XuKey Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, School of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China. xuwen@cqmu.edu.cn.ORCID 0000-0002-0762-4479
Children's Hospital of Chongqing Medical University · CNFirst People’s Hospital of Zunyi · CNZunyi Medical University · CN

Funding

Health Commission of Guizhou Province QianWeijianhan [2021]160National Natural Science Foundation of China 82270030
6 · The paper itself

Abstract

backgroundEarly microbial exposure is associate with protective allergic asthma. We have previously demonstrated that Streptococcus pneumoniae aminopeptidase N (PepN), one of the pneumococcal components, inhibits ovalbumin (OVA) -induced airway inflammation in murine models of allergic asthma, but the underlying mechanism was incompletely determined.

methodsBALB/c mice were pretreated with the PepN protein and exposed intranasally to HDM allergen. The anti-inflammatory mechanisms were investigated using depletion and adoptive transfer experiments as well as transcriptome analysis and isolated lung CD11c

resultsWe found pretreatment of mice with PepN promoted the proliferation of lung-resident F4/80

conclusionOur results demonstrated that the expansion of CD11c

Indexed as

AsthmaPneumoniaAnimalsAnti-Inflammatory AgentsCD13 AntigensCytokinesDisease Models, AnimalInflammationLungMacrophagesMiceMice, Inbred BALB COvalbuminPhenotypeStreptococcus pneumoniaeAnti-Inflammatory AgentsCD13 AntigensCytokinesOvalbuminAllergic asthmaHygiene hypothesisMacrophageOxidation phosphorylationStreptococcus pneumoniae aminopeptidase N

Identifiers

PMID38082290
PMCPMC10712085
OpenAlexW4389559843

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.