Evidence map›Paper›PMID 38082190›Full record

ArticlePharmacological reports : PR2024

New gold(III) complexes TGS 121, 404, and 702 show anti-tumor activity in colitis-induced colorectal cancer: an in vitro and in vivo study.

Jakub Włodarczyk, Julia Krajewska, Marcin Talar, Łukasz Szeleszczuk, Agata Gurba, Szymon Lipiec, Przemysław Taciak, Remigiusz Szczepaniak, Izabela Młynarczuk-Biały, Jakub Fichna

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In one paragraph

Article in Pharmacological reports : PR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Jakub WłodarczykDepartment of Biochemistry, Chair of Biochemistry and Chemistry, Faculty of Medicine, Medical University of Łódź, Mazowiecka 5, 92-215, Lodz, Poland.
Julia KrajewskaDepartment of Biochemistry, Chair of Biochemistry and Chemistry, Faculty of Medicine, Medical University of Łódź, Mazowiecka 5, 92-215, Lodz, Poland.
Marcin TalarDepartment of Biochemistry, Chair of Biochemistry and Chemistry, Faculty of Medicine, Medical University of Łódź, Mazowiecka 5, 92-215, Lodz, Poland.
Łukasz SzeleszczukDepartment of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-093, Warsaw, Poland.
Agata GurbaDepartment of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-093, Warsaw, Poland.
Szymon LipiecHESA at the Department for Histology and Embryology, Medical University of Warsaw, Chałubińskiego 5, 02-004, Warsaw, Poland.
Przemysław TaciakDepartment of Pharmacodynamics, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1 Str., 02-093, Warsaw, Poland.
Remigiusz SzczepaniakInwex Ltd., Solidarności 34, 25-323, Kielce, Poland.
Izabela Młynarczuk-BiałyDepartment for Histology and Embryology, Medical University of Warsaw, Chałubińskiego 5, 02-004, Warsaw, Poland.
Jakub FichnaDepartment of Biochemistry, Chair of Biochemistry and Chemistry, Faculty of Medicine, Medical University of Łódź, Mazowiecka 5, 92-215, Lodz, Poland. jakub.fichna@umed.lodz.pl.ORCID http://orcid.org/0000-0002-8443-4417
Medical University of Warsaw · PLMedical University of Lodz · PL

Funding

National Science Center (PL) #UMO-2017/25/B/NZ5/02848 toUniwersytet Medyczny w Lodzi #503/1-156-04/503-11-001
6 · The paper itself

Abstract

backgroundChronic inflammation in the course of inflammatory bowel disease may result in colon cancer, or colitis-associated colorectal cancer (CACRC). It is well established that CACRC is associated with oxidative stress and secretion of multiple pro-inflammatory cytokines, e.g. tumor necrosis factor-α. Recently, we proved that the administration of gold(III) complexes resulted in the alleviation of acute colitis in mice. The aim of the current study was to assess the antitumor effect of a novel series of gold(III) complexes: TGS 121, 404, 512, 701, 702, and 703. MATERIALS: Analyzed gold(III) complexes were screened in the in vitro studies using colorectal cancer and normal colon epithelium cell lines, SW480, HT-29, and CCD 841 CoN, and in vivo, in the CACRC mouse model.

resultsOf all tested complexes, TGS 121, 404, and 702 exhibited the strongest anti-tumor effect in in vitro viability assay of colon cancer cell lines and in in vivo CACRC model, in which these complexes decreased the total number of colonic tumors and macroscopic score. We also evidenced that the mechanism of action was linked to the enzymatic antioxidant system and inflammatory cytokines.

conclusionsTGS 121, 404, and 702 present anti-tumor potential and are an attractive therapeutic option for colorectal cancer.

Indexed as

ColitisColonic NeoplasmsColorectal NeoplasmsAnimalsColonCytokinesDextran SulfateGoldHT29 CellsHumansMiceMice, Inbred C57BLCytokinesDextran SulfateGoldAnti-tumorCarcinogenesisColitis-associated colorectal cancerColorectal cancerGold

Identifiers

PMID38082190
PMCPMC10830623
OpenAlexW4389546065

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.