Evidence map›Paper›PMID 38082030›Full record

ArticleDrug delivery and translational research2024

Small molecule-engineered nanoassembly for lipid peroxidation-amplified photodynamic therapy.

Yuting Wang, Yuequan Wang, Yuting Liu, Mingyang Zhou, Xianbao Shi, Xiaohui Pu, Zhonggui He, Shenwu Zhang, Feng Qin, Cong Luo

Abstract read
PubMed Publisher
In one paragraph

Article in Drug delivery and translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yuting Wang *Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Yuequan Wang *Department of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Yuting LiuDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Mingyang ZhouDepartment of Chemistry, University of Pennsylvania, Philadelphia, PA, USA.
Xianbao ShiDepartment of Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Xiaohui PuState Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, N. Jinming Ave, Kaifeng, 475004, China.
Zhonggui HeDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
Shenwu ZhangDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China. zhangshenwu@aliyun.com.
Feng QinCollege of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China. qf-1998@163.com.
Cong LuoDepartment of Pharmaceutics, Wuya College of Innovation, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China. luocong@syphu.edu.cn.ORCID 0000-0002-0506-9598
Shenyang Pharmaceutical University · CNAffiliated Hospital of Jining Medical University · CNHenan University · CNUniversity of Pennsylvania · US

Funding

Basic Research Projects of Liaoning Provincial Department of Education LJKZZ20220109National Natural Science Foundation of China 82204317Natural Science Foundation of Liaoning Province 2022-BS-162Shenyang Youth Science and Technology Innovation Talents Program RC210452
6 · The paper itself

Abstract

Photodynamic therapy (PDT), extensively explored as a non-invasive and spatio-temporal therapeutic modality for cancer treatment, encounters challenges related to the brief half-life and limited diffusion range of singlet oxygen. Lipid peroxides, formed through the oxidation of polyunsaturated fatty acids by singlet oxygen, exhibit prolonged half-life and potent cytotoxicity. Herein, we employed small molecule co-assembly technology to create nanoassemblies of pyropheophorbide a (PPa) and docosahexaenoic acid (DHA) to bolster PDT. DHA, an essential polyunsaturated fatty acid, co-assembled with PPa to generate nanoparticles (PPa@DHA NPs) without the need for additional excipients. To enhance the stability of these nanoassemblies, we introduced 20% DSPE-PEG

Indexed as

ChlorophyllDocosahexaenoic AcidsLipid PeroxidationNanoparticlesPhotochemotherapyAnimalsCell Line, TumorFemaleHumansMiceMice, Inbred BALB CPhosphatidylethanolaminesPhotosensitizing AgentsPolyethylene GlycolsSinglet OxygenChlorophyllDocosahexaenoic AcidsPhosphatidylethanolaminesPhotosensitizing AgentsPolyethylene Glycolspyropheophorbide aSinglet OxygenDocosahexaenoic acidLipid peroxidesPhotodynamics therapyPyropheophorbide aSelf-assembly

Identifiers

PMID38082030
OpenAlexW4389580151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.