Evidence map›Paper›PMID 38081970›Full record

ArticleNature biotechnology2024

A monomeric StayGold fluorescent protein.

Esther Ivorra-Molla, Dipayan Akhuli, Martin B L McAndrew, William Scott, Lokesh Kumar, Saravanan Palani, Masanori Mishima, Allister Crow, Mohan K Balasubramanian

Abstract read
In one paragraph

Article in Nature biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed.

  1. Review
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  5. Review
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  8. Gap junctions in the alimentary tract regulate reproductive span inbioRxiv : the preprint server for biology · 2026
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  11. Article
  12. Review
  13. Article
  14. Identification of optimal fluorophores for use in theMolecular biology of the cell · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Esther Ivorra-Molla *Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.ORCID http://orcid.org/0009-0006-7082-2968
Dipayan Akhuli *Centre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0002-7901-1006
Martin B L McAndrewSchool of Life Sciences, University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0001-7338-3119
William ScottCentre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.ORCID http://orcid.org/0009-0004-8774-2935
Lokesh KumarCentre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.ORCID http://orcid.org/0000-0002-1130-0792
Saravanan PalaniDepartment of Biochemistry, Indian Institute of Science, Bangalore, India.ORCID http://orcid.org/0000-0002-1893-6777
Masanori MishimaCentre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK. m.mishima@warwick.ac.uk.ORCID http://orcid.org/0000-0002-8908-7485
Allister CrowSchool of Life Sciences, University of Warwick, Coventry, UK. allister.crow@warwick.ac.uk.ORCID http://orcid.org/0000-0001-6856-5962
Mohan K BalasubramanianCentre for Mechanochemical Cell Biology and Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK. m.k.balasubramanian@warwick.ac.uk.ORCID http://orcid.org/0000-0002-1292-8602

Funding

DBT India Alliance (Wellcome Trust/DBT India Alliance) IA/I/21/1/505633DBT-Wellcome Trust India Alliance IA/I/21/1/505633DST | Science and Engineering Research Board (SERB) SERB-SRG/2021/001600RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/V017101/1RCUK | MRC | Medical Research Foundation MR/N014294/1Wellcome Trust 101885Wellcome Trust (Wellcome) WT101885MA
6 · The paper itself

Abstract

StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite favorable fluorescence properties, use of StayGold as a fluorescent tag is limited because it forms a natural dimer. Here we report the 1.6 Å structure of StayGold and generate a derivative, mStayGold, that retains the brightness and photostability of the original protein while being fully monomeric.

Indexed as

Luminescent ProteinsCrystallography, X-RayModels, MolecularProtein ConformationLuminescent Proteins

Identifiers

PMID38081970
PMCPMC11392804

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.