Evidence map›Paper›PMID 38081939›Full record

ArticleCommunications biology2023

Thyroid hormone-regulated chromatin landscape and transcriptional sensitivity of the pituitary gland.

Young-Wook Cho, Yulong Fu, Chen-Che Jeff Huang, Xuefeng Wu, Lily Ng, Kevin A Kelley, Kristen R Vella, Anders H Berg, Anthony N Hollenberg, Hong Liu and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Summary of the Year in Review Lectures at the 2024 Annual Meeting of the American Thyroid Association.Thyroid : official journal of the American Thyroid Association · 2025
    Article
  5. Article
  6. Thyroid Hormone Action by Genomic and Nongenomic Molecular Mechanisms.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Young-Wook Cho *Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-8247-5995
Yulong Fu *Laboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Chen-Che Jeff HuangLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0003-0376-4682
Xuefeng WuLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Lily NgLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-8942-9908
Kevin A KelleyDepartment of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, New York, 10029, USA.
Kristen R VellaDivision of Endocrinology, Diabetes and Metabolism, Weill Department of Medicine Weill Cornell Medicine, New York, New York, 10065, USA.
Anders H BergDepartment of Pathology, Cedars Sinai Medical Center, Los Angeles, California, 90048, USA.
Anthony N HollenbergDivision of Endocrinology, Diabetes and Metabolism, Weill Department of Medicine Weill Cornell Medicine, New York, New York, 10065, USA.
Hong LiuLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA.
Douglas ForrestLaboratory of Endocrinology and Receptor Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA. forrestd@niddk.nih.gov.ORCID 0000-0002-3463-4162
National Institutes of Health · USCornell University · USCedars-Sinai Medical Center · USIcahn School of Medicine at Mount Sinai · US

Funding

Tissue-specific functions of thyroid hormone receptorsZIADK047037 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI FORREST, DOUGLAS · 2009 to 2025
$13.3M
COREPRESSOR REGULATION OF THYROID HORMONE ACTIONR01DK056123 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOLLENBERG, ANTHONY N · 2000 to 2023
$7.6M
Thyroid Hormone Signaling in Human HepatocytesR01DK117940 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOLLENBERG, ANTHONY N, WILSON, ANDREW A · 2019 to 2022
$2.7M
Hypothalamic regulation by thyroid hormone receptor phosphorylationR01DK136661 · NIDDK · UNIVERSITY OF ARIZONA · PI ANTHONY N HOLLENBERG, FREDRIC E. WONDISFORD · 2023 to 2026
$2.5M
Corepressor Regulation of Nuclear Receptor ActionR56DK056123 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI HOLLENBERG, ANTHONY N · 2009 to 2009
$425k
NIDDK NIH HHS R01 DK056123NIDDK NIH HHS R01 DK117940NIDDK NIH HHS R01 DK136661NIDDK NIH HHS R56 DK056123
6 · The paper itself

Abstract

Thyroid hormone (3,5,3'-triiodothyronine, T3) is a key regulator of pituitary gland function. The response to T3 is thought to hinge crucially on interactions of nuclear T3 receptors with enhancers but these sites in pituitary chromatin remain surprisingly obscure. Here, we investigate genome-wide receptor binding in mice using tagged endogenous thyroid hormone receptor β (TRβ) and analyze T3-regulated open chromatin using an anterior pituitary-specific Cre driver (Thrb

Indexed as

ChromatinThyroid HormonesAnimalsMicePituitary GlandThyroid Hormone Receptors betaTriiodothyronineChromatinThyroid Hormone Receptors betaThyroid HormonesTriiodothyronine

Identifiers

PMID38081939
PMCPMC10713718
OpenAlexW4389545991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.