Evidence map›Paper›PMID 38081873›Full record

ArticleSchizophrenia (Heidelberg, Germany)2023

Age-associated alterations in thalamocortical structural connectivity in youths with a psychosis-spectrum disorder.

Lydia Lewis, Mary Corcoran, Kang Ik K Cho, YooBin Kwak, Rebecca A Hayes, Bart Larsen, Maria Jalbrzikowski

Abstract read
In one paragraph

Article in Schizophrenia (Heidelberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lydia Lewis *Institute of Child Development, University of Minnesota, Minneapolis, MN, USA.
Mary Corcoran *Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
Kang Ik K ChoPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
YooBin KwakDepartment of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea.
Rebecca A HayesDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
Bart LarsenDepartment of Pediatrics, Masonic Institute for the Developing Brain, University of Minnesota, Minneapolis, MN, USA.
Maria JalbrzikowskiDepartment of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA. maria.jalbrzikowski@childrens.harvard.edu.ORCID http://orcid.org/0000-0001-6574-9432

Funding

Predicting psychosis risk in youth using a novel structural neuroimaging score that measures deviation from normative development. Can we bring it to communities using portable, low-field MRI?R01MH129636 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI MARIA JALBRZIKOWSKI · 2022 to 2026
$3.8M
Neurodevelopmental variation of intrinsic functional connectivity and its relationship to psychosis risk and gene expression - SupplementK01MH112774 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JALBRZIKOWSKI, MARIA · 2017 to 2022
$884k
Brain iron as a neurodevelopmental mechanism for transdianostic executive dysfunctionR00MH127293 · NIMH · UNIVERSITY OF MINNESOTA · PI Bart Larsen · 2023 to 2026
$821k
NIMH NIH HHS K01 MH112774NIMH NIH HHS R00 MH127293NIMH NIH HHS R01 MH129636
6 · The paper itself

Abstract

Psychotic symptoms typically emerge in adolescence. Age-associated thalamocortical connectivity differences in psychosis remain unclear. We analyzed diffusion-weighted imaging data from 1254 participants 8-23 years old (typically developing (TD):N = 626, psychosis-spectrum (PS): N = 329, other psychopathology (OP): N = 299) from the Philadelphia Neurodevelopmental Cohort. We modeled thalamocortical tracts using deterministic fiber tractography, extracted Q-Space Diffeomorphic Reconstruction (QSDR) and diffusion tensor imaging (DTI) measures, and then used generalized additive models to determine group and age-associated thalamocortical connectivity differences. Compared to other groups, PS exhibited thalamocortical reductions in QSDR global fractional anisotropy (GFA, p-values range = 3.0 × 10

Identifiers

PMID38081873
PMCPMC10713597

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.