Evidence map›Paper›PMID 38081853›Full record

ArticleScientific reports2023

Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression.

Gabriel C Tobias, João L P Gomes, Larissa G Fernandes, Vanessa A Voltarelli, Ney R de Almeida, Paulo R Jannig, Rodrigo W Alves de Souza, Carlos E Negrão, Edilamar M Oliveira, Roger Chammas and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Gabriel C TobiasSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil. gct4001@med.cornell.edu.
João L P GomesSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Larissa G FernandesSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Vanessa A VoltarelliSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Ney R de AlmeidaSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Paulo R JannigSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Rodrigo W Alves de SouzaSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Carlos E NegrãoSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Edilamar M OliveiraSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Roger ChammasDepartment of Radiology and Oncology, Faculdade de Medicine, Universidade de São Paulo, São Paulo, Brazil.
Christiano R R AlvesSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil.
Patricia C BrumSchool of Physical Education and Sport, Universidade de São Paulo, Avenida Professor Mello Moraes, 65-Butantã, São Paulo, SP, 05508-030, Brazil. pcbrum@usp.br.
Universidade de São Paulo · BRHarvard University · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BR

Funding

CAPES-PROEX 0001Conselho Nacional de Desenvolvimento Científico e Tecnológico 306261/2016-2Fundação de Amparo à Pesquisa do Estado de São Paulo 13/21065-3Fundação de Amparo à Pesquisa do Estado de São Paulo 14/26797-5Fundação de Amparo à Pesquisa do Estado de São Paulo 15/04788-7Fundação de Amparo à Pesquisa do Estado de São Paulo 16/22835-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/02528-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2012/25240-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/03016-8Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/25830-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/22814-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/01478-0
6 · The paper itself

Abstract

Exercise training reduces the incidence of several cancers, but the mechanisms underlying these effects are not fully understood. Exercise training can affect the spleen function, which controls the hematopoiesis and immune response. Analyzing different cancer models, we identified that 4T1, LLC, and CT26 tumor-bearing mice displayed enlarged spleen (splenomegaly), and exercise training reduced spleen mass toward control levels in two of these models (LLC and CT26). Exercise training also slowed tumor growth in melanoma B16F10, colon tumor 26 (CT26), and Lewis lung carcinoma (LLC) tumor-bearing mice, with minor effects in mammary carcinoma 4T1, MDA-MB-231, and MMTV-PyMT mice. In silico analyses using transcriptome profiles derived from these models revealed that platelet factor 4 (Pf4) is one of the main upregulated genes associated with splenomegaly during cancer progression. To understand whether exercise training would modulate the expression of these genes in the tumor and spleen, we investigated particularly the CT26 model, which displayed splenomegaly and had a clear response to the exercise training effects. RT-qPCR analysis confirmed that trained CT26 tumor-bearing mice had decreased Pf4 mRNA levels in both the tumor and spleen when compared to untrained CT26 tumor-bearing mice. Furthermore, exercise training specifically decreased Pf4 mRNA levels in the CT26 tumor cells. Aspirin treatment did not change tumor growth, splenomegaly, and tumor Pf4 mRNA levels, confirming that exercise decreased non-platelet Pf4 mRNA levels. Finally, tumor Pf4 mRNA levels are deregulated in The Cancer Genome Atlas Program (TCGA) samples and predict survival in multiple cancer types. This highlights the potential therapeutic value of exercise as a complementary approach to cancer treatment and underscores the importance of understanding the exercise-induced transcriptional changes in the spleen for the development of novel cancer therapies.

Indexed as

Carcinoma, Lewis LungColonic NeoplasmsExercisePlatelet Factor 4Angiogenesis InhibitorsAnimalsCell Line, TumorImmunologic FactorsMiceMice, Inbred BALB CRNA, MessengerSplenomegalyAngiogenesis InhibitorsImmunologic FactorsPlatelet Factor 4RNA, Messenger

Identifiers

PMID38081853
PMCPMC10713653
OpenAlexW4389574031

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.