Evidence map›Paper›PMID 38081799›Full record

ArticleACS chemical biology2024

Biosynthesis of Haloterpenoids in Red Algae via Microbial-like Type I Terpene Synthases.

Taylor S Steele, Immo Burkhardt, Malia L Moore, Tristan de Rond, Hannah K Bone, Kerrie Barry, Victoria Mae Bunting, Jane Grimwood, Lori H Handley, Shanmugam Rajasekar and 3 more

Open access · greenAbstract read
In one paragraph

Article in ACS chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Laurinterol, the MainMarine drugs · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Biosynthesis of the Red Algal Diterpene Peyssonnosol in Bacteria.Angewandte Chemie (International ed. in English) · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Taylor S SteeleScripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Immo BurkhardtScripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0001-9515-4042
Malia L MooreScripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.
Tristan de RondScripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-5203-4662
Hannah K BoneScripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0009-0009-2237-7531
Kerrie BarryLawrence Berkeley National Laboratory, JGI - DOE Joint Genome Institute, Berkeley, California 94720, United States.
Victoria Mae BuntingArizona Genomics Institute, University of Arizona, Tucson, Arizona 85721, United States.
Jane GrimwoodGenome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, United States.
Lori H HandleyGenome Sequencing Center, HudsonAlpha Institute for Biotechnology, Huntsville, Alabama 35806, United States.ORCID 0000-0002-9968-6051
Shanmugam RajasekarArizona Genomics Institute, University of Arizona, Tucson, Arizona 85721, United States.
Jayson TalagArizona Genomics Institute, University of Arizona, Tucson, Arizona 85721, United States.
Todd P MichaelThe Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, United States.
Bradley S MooreScripps Institution of Oceanography, University of California San Diego, La Jolla, California 92093, United States.ORCID 0000-0002-4652-1253
Scripps Institution of Oceanography · USUniversity of Arizona · USHudsonAlpha Institute for Biotechnology · USSalk Institute for Biological Studies · USLawrence Berkeley National Laboratory · US

Funding

Natural Product Genome MiningR01GM085770 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JENSEN, PAUL R, MOORE, BRADLEY S · 2009 to 2024
$5.8M
Equipment Supplement - Biosynthesis of marine terpenoid natural productsR01GM146224 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GEOFFREY A CHANG, BRADLEY S MOORE · 2023 to 2026
$2.0M
Elucidating the genetic basis of imidazopyrazinone luciferin biosynthesis for the development of improved bioluminescence imaging technologiesF32GM129960 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DE ROND, TRISTAN · 2018 to 2020
$185k
NIGMS NIH HHS F32 GM129960NIGMS NIH HHS R01 GM085770NIGMS NIH HHS R01 GM146224
6 · The paper itself

Abstract

Red algae or seaweeds produce highly distinctive halogenated terpenoid compounds, including the pentabromochlorinated monoterpene halomon that was once heralded as a promising anticancer agent. The first dedicated step in the biosynthesis of these natural product molecules is expected to be catalyzed by terpene synthase (TS) enzymes. Recent work has demonstrated an emerging class of type I TSs in red algal terpene biosynthesis. However, only one such enzyme from a notoriously haloterpenoid-producing red alga (

Indexed as

Alkyl and Aryl TransferasesRhodophytaMonoterpenesTerpenesAlkyl and Aryl TransferasesMonoterpenesTerpenesterpene synthase

Identifiers

PMID38081799
PMCPMC10985283
OpenAlexW4389625078

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.