Trial reportBMJ (Clinical research ed.)2023
Efficacy of cola ingestion for oesophageal food bolus impaction: open label, multicentre, randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- The Classification for Adverse Events in GastRointEstinal Endoscopy (AGREE): Three-Year Evaluation and Additional Recommendations.Endoscopy international open · 2026Article
- Management of a Large Bone Impaction in the Esophagus With Cola and Catheters: A Case Report and Literature Review.Clinical case reports · 2026Article
- Early prediction and warning of MODS following major trauma via identification of cytokine storm: A prospective cohort study.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Esophageal Obstruction from Food Bolus Impaction Successfully Managed with the "Upright Posture, Chin Tuck, Double Swallow" Maneuver: A Case Report.Clinical practice and cases in emergency medicine · 2024Article
Corrections and comments
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Authors and funding
9 authors at 8 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the efficacy and safety of cola in resolving complete oesophageal food bolus impaction.
designOpen label, multicentre, randomised controlled trial.
settingEmergency departments of five Dutch hospitals at the secondary and tertiary level, between 22 December 2019 and 16 June 2022.
participants51 adults presenting with complete oesophageal food bolus impaction, defined as a sudden inability to pass saliva after consumption of foods. Patients who ingested meat that contained bones, and patients with an American Society of Anesthesiologists (ASA) physical status classification of IV or higher were excluded.
interventions28 patients in the intervention group were instructed to consume 25 mL cups of cola at intervals up to a maximum total volume of 200 mL. 23 patients in the control group awaited spontaneous passage. In either group, if complete resolution of symptoms did not occur, endoscopic removal was performed following current guidelines: within 6 hours for patients with complete obstruction, and within 24 hours for partial obstruction. In case of complete resolution of symptoms, elective diagnostic endoscopy was required.
main outcome measuresImprovement of oesophageal food bolus obstruction as reported by patients (ie, aggregate of complete and partial passage), and evaluation of complete passage. The secondary outcome was any intervention related adverse event.
resultsCola did not have a meaningful effect on the improvement of food bolus obstruction (17/28 (61%) intervention
conclusionsIn this study, cola consumption did not lead to a higher rate of improvement of complete oesophageal food bolus impaction. Given the lack of adverse events in the treatment group and some events of resolution after treatment, cola might be considered as a first line treatment, but should not delay any planning of endoscopic management.
trial registrationNetherlands Trial Register (currently International Clinical Trial Registry Platform) NL8312.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.