Evidence map›Paper›PMID 38081619›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[High expression of long noncoding RNA UCA1 promotes invasion, migration and epithelial-mesenchymal transition of trophoblasts

J Sun, Y Zhang, L Yang, L Zhou, X Lu, J Li, P Chen

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

J SunFirst Clinical College of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
Y ZhangFirst Clinical College of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
L YangFirst Clinical College of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
L ZhouFirst Clinical College of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
X LuDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450099, China.
J LiDepartment of Obstetrics and Gynecology, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450099, China.
P ChenFirst Clinical College of Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
Henan University of Traditional Chinese Medicine · CNFirst Affiliated Hospital of Henan University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the role of urothelial carcinoma antigen 1 (UCA1) in regulation of invasion, migration and epithelial-mesenchymal transition (EMT) of trophoblast HTR-8/SVneo cells and its association with tubal pregnancy.

methodsCultured HTR- 8/SVneo cells stimulated with interleukin-6 (IL-6) were examined for changes in UCA1 expression and cell migration ability using qRT-PCR and scratch assay, respectively. A HTR-8/SVneo cell model with UCA1 silencing was constructed by transient transfection, and the migration and invasion abilities of the cells were assessed using Scratch assay and Transwell assay; qRT-PCR and Western blotting were performed to detect the mRNA and protein expression levels of EMT markers.

resultsHTR-8/SVneo cells stimulated with IL-6 exhibited significantly increased migration ability and up-regulated expression of UCA1 (

conclusionUCA1 may be a key gene that promotes the occurrence of tubal pregnancy and thus provides a new therapeutic target for tubal pregnancy.

Indexed as

Epithelial-Mesenchymal TransitionPregnancy, TubalRNA, Long NoncodingCell MovementCell ProliferationFemaleHumansInterleukin-6PregnancyRNA, MessengerTrophoblastsInterleukin-6RNA, Long NoncodingRNA, MessengerUCA1 RNA, humanepithelial-mesenchymal transitioninvasionmigrationtubal pregnancyurothelial carcinoma antigen 1

Identifiers

PMID38081619
PMCPMC10713461
OpenAlexW4389803625

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.