Evidence map›Paper›PMID 38081606›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Sevoflurane alleviates ventilator-induced lung injury in rats by down-regulating the TRPV4/C-PLA2 signaling pathway].

W Wang, Y Yang, L Wang, X Guo, L Tian, H Wang, Y Hu, R Liu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

W WangDepartment of Anesthesiology, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong 675000, China.
Y YangExperimental Center of Medical Function, Kunming Medical University, Kunming 650500, China.
L WangDepartment of Anesthesiology, First People's Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China.
X GuoDepartment of Anesthesiology, First People's Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China.
L TianDepartment of Anesthesiology, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong 675000, China.
H WangDepartment of Anesthesiology, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong 675000, China.
Y HuDepartment of Anesthesiology, Chuxiong Yi Autonomous Prefecture People's Hospital, Chuxiong 675000, China.
R LiuDepartment of Anesthesiology, First People's Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China.
Chuxiong Normal University · CNKunming University of Science and Technology · CNKunming Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the mechanism underlying the protective effect of sevoflurane against ventilator-induced lung injury (VILI).

methodsThirty-two SD rats were randomized into mechanical ventilation (MV) group, MV+sevoflurane group (MS group), MV+sevoflurane+transient receptor potential vanillate subtype 4 (TRPV4) agonist group (MST group) and MV+ sevoflurane + vehicle group (MSV group). Arachidonic acid (AA) in the lung tissues was quantified with ELISA. TRPV4, cytoplasmic phospholipase A2 (C-PLA2) and myosin light chain kinase (MLCK) protein expressions were detected by Western blotting. Lung injury in the rats was evaluated by assessing MLCK protein expression level, pulmonary permeability index, lung wet/dry ratio, leukocyte count in the bronchoalveolar lavage fluid (BALF), myeloperoxidase content in lung tissue, and histological score of the lungs.

resultsThe rats in MV group showed significantly increased TRPV4 and C-PLA2 expression levels in the lung tissues with increased lung permeability and obvious lung inflammation compared with those in the other 3 groups (

conclusionSevoflurane protects against VILI in rats by down-regulating the TRPV4/C-PLA2 signaling pathway.

Indexed as

TRPV Cation ChannelsVentilator-Induced Lung InjuryAnimalsBronchoalveolar Lavage FluidLungPhospholipases A2RatsRats, Sprague-DawleySevofluraneSignal TransductionPhospholipases A2SevofluraneTRPV Cation Channelscytoplasmic phospholipase A2mechanical ventilationsevofluranetransient receptor potential vanillate subtype 4ventilator-induced lung injury

Identifiers

PMID38081606
PMCPMC10713460
OpenAlexW4389800267

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.