Evidence map›Paper›PMID 38081602›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023

[Quantitative analysis of differential proteins in renal tissues of rats with chronic intermittent hypoxic exposure based on TMT and PRM technology].

M Wei, N Chen, J Li, D Liu, S Shen, F Wang, R Wu, Q Chen

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

M WeiCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
N ChenCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
J LiCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
D LiuCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
S ShenCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
F WangCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
R WuCollege of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Q ChenClinical Skills Teaching Center, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Fujian University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo screen the differentially expressed proteins in the kidneys of rats exposed to chronic intermittent hypoxia (CIH) based on TMT-PRM technology to identify the potential biomarkers of renal injuries induced by CIH.

methodsTwenty SD rats were randomized into two groups (

resultsCIH induced obvious renal injury in the rats, manifested by irregular glomerulus and swelling of the epithelial cells of the renal tubules. A total of 31 differentially expressed proteins were identified in CIH rats, including 22 up-regulated and 9 down-regulated proteins. Enrichment analysis of GO function and KEGG pathway analysis showed that the differentially expressed proteins participated mainly in the biological processes of cell adhesion, hypoxic stress, and calcium ions and were involved in the PPAR, AMPK, and metabolic pathways. In PRM quantitative analysis, 3 proteins, namely P07379 (PCK1), P19132 (Fth1) and Q5XI79 (Ndufaf7), showed results consistent with those of TMT-quantitative proteomic analysis.

conclusionThirty-one differentially expressed proteins were identified in the renal tissues of rats with CIH exposure, and among them P07379 (PCK1), P19132 (Fth1), and Q5XI79 (Ndufaf7) may be the key proteins closely related to the renal injury in induced by CIH.

Indexed as

ProteomicsTandem Mass SpectrometryAnimalsChromatography, LiquidHypoxiaRatsRats, Sprague-Dawleychronic intermittent hypoxiakidneyPRMproteomesTMT

Identifiers

PMID38081602
PMCPMC10713465
OpenAlexW4389803572

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.