ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2023
[Circular RNA hsa_circ_0006834 is a potential prognostic biomarker for hepatocellular carcinoma].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors at 1 institution in 1 country.
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Abstract
objectiveTo explore the differentially expressed circular RNAs (circRNAs) in hepatocellular carcinoma (HCC) and their association with clinical features and prognosis of HCC patients.
methodsRNA sequencing was performed on 56 pairs of HCC and adjacent tissues to identify the differentially expressed circRNAs in HCC, whose expressions were validated by RT-qPCR in another 15 pairs of HCC and adjacent tissues. The correlation of the selected circRNAs with the clinical features and prognosis of the patients was analyzed using Chi-square test, Cox proportional hazards regression model and Kaplan-Meier analysis. The predictive value of the identified circRNA for recurrence-free survival and overall survival of HCC patients was assessed using ROC curves.
resultsWe identified 17 significantly up-regulated and 45 down-regulated circRNAs in HCC tissues using RNA sequencing (
conclusionhsa_circ_0006834 is a new potential biomarker for evaluating the prognosis of HCC patients.
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