Evidence map›Paper›PMID 38081518›Full record

ArticleBehavioural brain research2024

Model-based parcellation of diffusion MRI of injured spinal cord predicts hand use impairment and recovery in squirrel monkeys.

Isaac V Manzanera Esteve, Feng Wang, Jamie L Reed, Hui Xin Qi, Wesley Thayer, John C Gore, Li Min Chen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Isaac V Manzanera EsteveDepartment of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: isaac.v.manzanera.esteve@vumc.org.
Feng WangVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Jamie L ReedVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Hui Xin QiDepartment of Psychology, Vanderbilt University, Nashville, TN, USA.
Wesley ThayerDepartment of Plastic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
John C GoreVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Li Min ChenVanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Vanderbilt University Medical Center · USVanderbilt University · US

Funding

Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
Biophysical Basis of Functional Connectivity by MRIR01NS078680 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Li Min Chen, John C Gore · 2012 to 2026
$7.6M
Resting State Connectivity in Primate Spinal CordR01NS092961 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CHEN, LI MIN, GORE, JOHN C · 2016 to 2025
$5.3M
Resting State FMRI as a Biomarker of Functional Integrity of Spinal CordR01NS104149 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2017 to 2020
$1.5M
Upgrade of a 9.4T MRI Animal ScannerS10OD025085 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GORE, JOHN C · 2020 to 2020
$600k
NICHD NIH HHS P50 HD103537NIH HHS S10 OD025085NINDS NIH HHS R01 NS078680NINDS NIH HHS R01 NS092961NINDS NIH HHS R01 NS104149
6 · The paper itself

Abstract

A mathematical model-based parcellation of magnetic resonance diffusion tensor images (DTI) has been developed to quantify progressive changes in three types of tissues - grey (GM), white matter (WM), and damaged spinal cord tissue, along with behavioral assessments over a 6 month period following targeted spinal cord injuries (SCI) in monkeys. Sigmoid Gompertz function based fittings of DTI metrics provide early indicators that correlate with, and predict, recovery of hand grasping behavior. Our three tissue pool model provided unbiased, data-driven segmentation of spinal cord images and identified DTI metrics that can serve as reliable biomarkers of severity of spinal cord injuries and predictors of behavioral outcomes.

Indexed as

Diffusion Tensor ImagingSpinal Cord InjuriesAnimalsDiffusion Magnetic Resonance ImagingHumansSaimiriSpinal CordBehavioral outcomeDiffusion tensor imagesGompertz functionLongitudinal quantitative recoverySpinal cord injuryTissue parcellation model

Identifiers

PMID38081518
PMCPMC10865381
OpenAlexW4389513898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.