Article in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
49 authors at 20 institutions in 14 countries.
Iain R TimminsDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-8761-582X
Michael E JonesDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.ORCID 0000-0002-1931-1349
Hans-Olov AdamiClinical Effectiveness Group, Institute of Health and Society, University of Oslo, Oslo, Norway.ORCID 0000-0001-9592-5791
Dagfinn AuneDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom.ORCID 0000-0002-4533-1722
Laura BagliettoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0002-8193-7529
Kimberly A BertrandSlone Epidemiology Center at Boston University, Boston, MA.ORCID 0000-0002-4565-7618
Kristen D BrantleyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0003-0084-4775
Yu ChenDivision of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, New York, NY.
Jessica Clague DeHartSchool of Community and Global Health, Claremont Graduate University, Claremont, CA.ORCID 0000-0002-2298-3146
Tess V ClendenenDivision of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, New York, NY.ORCID 0000-0003-4170-6977
Laure DossusNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.ORCID 0000-0003-2716-5748
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0002-3961-6609
Olivia FletcherThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0001-9387-7116
Agnès FournierUVSQ, CESP, Gustave Roussy, Team "Exposome, Heredity, Cancer, and Health", INSERM, Paris-Saclay University, Paris-South University, Villejuif, France.ORCID 0000-0001-8380-3439
Niclas HåkanssonUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7673-5554
Susan E HankinsonDepartment of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA.
Richard S HoulstonDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.ORCID 0000-0002-5268-0242
Corinne E JoshuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.ORCID 0000-0002-5100-172X
Victoria A KirshOntario Institute for Cancer Research, Toronto, ON, Canada.ORCID 0000-0003-2422-2225
Cari M KitaharaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.ORCID 0000-0001-6416-4432
Woon-Puay KohHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Martha S LinetDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD.ORCID 0000-0002-1687-5587
Hannah Lui ParkDepartment of Pathology and Laboratory Medicine, Department of Epidemiology, UC Irvine School of Medicine, Irvine, CA.ORCID 0000-0001-9973-1396
Brigid M LynchCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.ORCID 0000-0001-8060-547X
Anne M MayJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.ORCID 0000-0003-0643-3790
Fulvio RicceriDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, and Public Health, University of Turin, Turin, Italy.
Thomas E RohanAlbert Einstein College of Medicine, Bronx, NY.
Maria-Jose SánchezEscuela Andaluza de Salud Pública (EASP), Granada, Spain.ORCID 0000-0003-4817-0757
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0002-0711-8314
Karl Smith-ByrneCancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom.
Karen SteindorfDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-5215-5651
Malin SundDepartment of Surgical and Perioperative Sciences/Surgery, Umeå University, Umeâ, Sweden.ORCID 0000-0002-7516-9543
Celine M VachonDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN.ORCID 0000-0002-1962-9322
Lars J VattenDepartment of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0003-2333-5252
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD.ORCID 0000-0002-0582-8005
Elisabete WeiderpassInternational Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0003-2237-0128
Walter C WillettDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA.ORCID 0000-0003-1458-7597
Alicja WolkUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Jian-Min YuanDivision of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, PA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-1226-070X
Hazel B NicholsDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC.ORCID 0000-0003-0972-1560
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC.ORCID 0000-0002-6776-0018
Anthony J SwerdlowDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Minouk J SchoemakerDivision of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.
Institute of Cancer Research · GBBoston University · USBrigham and Women's Hospital · USCentre international de recherche sur le cancer · FRJohns Hopkins University · USKarolinska Institutet · SENational Cancer Institute · USNational Institute of Environmental Health Sciences · USNew York University · USVanderbilt University · USAgency for Science, Technology and Research · SGAlbert Einstein College of Medicine · USAstraZeneca (United Kingdom) · GBBaker Heart and Diabetes Institute · AUClaremont Graduate University · USDanish Cancer Society · DKGerman Cancer Research Center · DEHarvard University · USInserm · FRMayo Clinic in Arizona · US
Funding
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Studies of Populations Exposed to Occupational Sources of RadiationZIACP010133 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI KITAHARA, CARI · 2009 to 2025
$34.2M
A Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0M
Environmental and Genetic Risk Factors For Breast Cancer: The Sister StudyZIAES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 2009 to 2025
$22.7M
FOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7M
Training Program in Cancer EpidemiologyT32CA009001 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI A. Heather Eliassen, Meir Stampfer · 1985 to 2026
$17.3M
Prospective studies of cancer etiology and prevention in Shanghai and SingaporeR01CA144034 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2010 to 2014
$7.0M
THE SINGAPORE COHORT STUDY OF DIET AND CANCERR01CA080205 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI YUAN, JIAN-MIN · 1999 to 2009
$5.3M
Cancer epidemiology cohorts in Shanghai and Singapore UM1CA182876 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YUAN, JIAN-MIN · 2014 to 2018
$4.3M
Genetic and Environmental Risk Factors for Breast Cancer: The Sister StudyZ01ES044005 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI SANDLER, DALE P · 1999 to 2008
$1.3M
Cancer Research UK 25514Intramural NIH HHS Z01 ES044005NCI NIH HHS R01 CA058420NCI NIH HHS R01 CA080205NCI NIH HHS R01 CA144034NCI NIH HHS T32 CA009001NCI NIH HHS U01 CA164974NCI NIH HHS UM1 CA182876NIEHS NIH HHS P30 ES010126World Health Organization 001
6 · The paper itself
Abstract
purposeThere is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study was to examine the association of physical activity with the risk of developing premenopausal breast cancer.
methodsWe pooled individual-level data on self-reported leisure-time physical activity across 19 cohort studies comprising 547,601 premenopausal women, with 10,231 incident cases of breast cancer. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% CIs for associations of leisure-time physical activity with breast cancer incidence. HRs for high versus low levels of activity were based on a comparison of risk at the 90th versus 10th percentiles of activity. We assessed the linearity of the relationship and examined subtype-specific associations and effect modification across strata of breast cancer risk factors, including adiposity.
resultsOver a median 11.5 years of follow-up (IQR, 8.0-16.1 years), high versus low levels of leisure-time physical activity were associated with a 6% (HR, 0.94 [95% CI, 0.89 to 0.99]) and a 10% (HR, 0.90 [95% CI, 0.85 to 0.95]) reduction in breast cancer risk, before and after adjustment for BMI, respectively. Tests of nonlinearity suggested an approximately linear relationship (
conclusionThis large, pooled analysis of cohort studies adds to evidence that engagement in higher levels of leisure-time physical activity may lead to reduced premenopausal breast cancer risk.
Indexed as
Breast NeoplasmsCohort StudiesExerciseFemaleHumansLeisure ActivitiesObesityRisk Factors
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
International Pooled Analysis of Leisure-Time Physical Activity and Premenopausal Breast Cancer in Women From 19 Cohorts. · full record | OpenQuestion