ArticleProceedings of the National Academy of Sciences of the United States of America2023
Association of cumulative loneliness with all-cause mortality among middle-aged and older adults in the United States, 1996 to 2019.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Loneliness, social isolation, and living alone: a comprehensive systematic review, meta-analysis, and meta-regression of mortality risks in older adults.Aging clinical and experimental research · 2025Pooled it
- Incremental Information from Repeated Loneliness Assessments in Middle-Aged and Older Adults.Healthcare (Basel, Switzerland) · 2026Article
- The dynamic interplay between loneliness and health behaviors from adolescence to midlife: A Norwegian population-based cohort study.Psychological medicine · 2026Article
- Associations of changes in social isolation and loneliness with all-cause mortality among older adults: a prospective cohort study.GeroScience · 2026Article
- The combined impact of social isolation and unhealthy risk score on mortality risk: a study from two prospective cohorts.BMC public health · 2026Article
- Loneliness and all-cause mortality in the United States.PloS one · 2026Article
- Resilience and loneliness among older adults: an analysis using decision tree techniques.Aging clinical and experimental research · 2025Article
- Loneliness and Risk of 30-Day Hospital Readmission After Acute Myocardial Infarction.Medical care · 2025Article
- The Role of Daily Calls to Telephone Companionship Lines for Older Adults Experiencing Chronic Loneliness.Annals of the New York Academy of Sciences · 2025Article
- Loneliness and social isolation among middle-aged and older adults with SLE: a single centre cross-sectional study.Rheumatology (Oxford, England) · 2025Article
- Companionship and Sharing Create Social Connections of an Online Community-Based Intervention for Patients with Cancer Receiving Outpatient Care: Pilot Study.JMIR cancer · 2025Article
- Cumulative loneliness and memory function among U.S. older adults: the role of depressive symptoms.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Identifying health conditions in older adults in textual health records using deep learning-based natural language processing.Computational and structural biotechnology journal · 2025Article
- "It just isn't the same": altered routines among older Americans three years after the COVID-19 pandemic onset.Frontiers in public health · 2025Article
- Loneliness and all cause mortality in Australian women aged 45 years and older: causal inference analysis of longitudinal data.BMJ medicine · 2025Article
- Social isolation and loneliness and their association with all-cause mortality. A population-based longitudinal study in Norway: The Tromsø Study 1994-2023.Preventive medicine reports · 2024Article
- Prevalence of Unwanted Loneliness and Associated Factors in People over 65 Years of Age in a Health Area of the Region of Murcia, Spain: HELPeN Project.Journal of clinical medicine · 2024Article
- Loneliness Trajectories and Chronic Loneliness Around the World.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Loneliness is a growing public health concern worldwide. We characterized the association between cumulative loneliness and subsequent all-cause mortality, using data from 9,032 participants aged 50+ in the population-based US Health and Retirement Study (HRS) from 1996 to 2019. Loneliness status (yes; no) was measured biennially from 1996 to 2004, and we categorized the experience of cumulative loneliness over the 8-y period as never, one time point, two time points, and ≥three time points. A multivariable-adjusted age-stratified Cox proportional hazards regression model was fitted to examine the association between cumulative loneliness from 1996 to 2004 and all-cause mortality from 2004 to 2019. Excess deaths due to each category of cumulative loneliness were calculated. Compared to those who never reported loneliness from 1996 to 2004, participants experiencing loneliness at one time point, two time points, and ≥three time points respectively had 1.05 (95% CI: 0.96 to 1.15), 1.06 (95% CI: 0.95 to 1.19), and 1.16 (95% CI: 1.02 to 1.33) times higher hazards of mortality from 2004 to 2019 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.