Evidence map›Paper›PMID 38079380›Full record

ArticleAccounts of chemical research2024

Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications.

Li-Sheng Zhang, Qing Dai, Chuan He

Open access · hybridAbstract read
In one paragraph

Article in Accounts of chemical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 31 citations in OpenAlex.

  1. Beyond mBiomedicines · 2026
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  9. RNA modifications and cancer ferroptosis.Cancer cell international · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 2 countries.

Li-Sheng ZhangDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Qing DaiDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.
Chuan HeDepartment of Chemistry, The University of Chicago, Chicago, Illinois 60637, United States.ORCID 0000-0003-4319-7424
Howard Hughes Medical Institute · US

Funding

Transcriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4M
Howard Hughes Medical InstituteNHGRI NIH HHS RM1 HG008935
6 · The paper itself

Abstract

RNA molecules are not merely a combination of four bases of A, C, G, and U. Chemical modifications occur in almost all RNA species and play diverse roles in gene expression regulation. The abundant cellular RNAs, such as ribosomal RNA (rRNA) and transfer RNA (tRNA), are known to have the highest density of RNA modifications, which exert critical functions in rRNA and tRNA biogenesis, stability, and subsequent translation. In recent years, modifications on low-abundance RNA species in mammalian cells, such as messenger RNA (mRNA), regulatory noncoding RNA (ncRNA), and chromatin-associated RNA (caRNA), have been shown to contain multiple different chemical modifications with functional significance. As the most abundant mRNA modification in mammals,

Indexed as

RNA, TransferTranscriptomeAnimalsBase SequenceMammalsMethylationRNARNA, MessengerRNARNA, MessengerRNA, Transfer

Identifiers

PMID38079380
PMCPMC10765377
OpenAlexW4389547195

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.